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InterPro: IPR001674 GMP synthase, C-terminal

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Matches:

1897 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
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Accession

IPR001674 GMP_synth_C

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF00958	GMP_synt_C	1896
TIGRFAMs	TIGR00884	guaA_Cterm	1795
Signatures in BioMart

InterPro Relationships Help

Contains

IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
IPR018318 tRNA methyl transferase-like

GO Term annotation Help

Process

GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process

Function

GO:0003922 GMP synthase (glutamine-hydrolyzing) activity
GO:0005524 ATP binding

InterPro annotation

Entry Details in BioMart

Abstract

The amidotransferase family of enzymes utilises the ammonia derived from the hydrolysis of glutamine for a subsequent chemical reaction catalyzed by the same enzyme. The ammonia intermediate does not dissociate into solution during the chemical transformations [1]. GMP synthetase is a glutamine amidotransferase from the de novo purine biosynthetic pathway. The C-terminal domain is specific to the GMP synthases EC:6.3.5.2. In prokaryotes this domain mediates dimerisation. Eukaryotic GMP synthases are monomers. This domain in eukaryotes includes several large insertions that may form globular domains [2].

Structural links Help

PDB - click here

SCOP: c.26.2.1 , d.52.2.1

CATH: 3.30.300.10 , 3.40.50.620

Database links Help

Enzyme: EC:6.3.5.2

PANDIT: PF00958

Blocks: IPB001674

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001674

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P38625 GMP synthase [glutamine-hydrolyzing]

P49057 GMP synthase [glutamine-hydrolyzing]

P49915 GMP synthase [glutamine-hydrolyzing]

Q09580 Probable GMP synthase [glutamine-hydrolyzing]

Q3THK7 GMP synthase [glutamine-hydrolyzing]

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR011702	Glutamine amidotransferase superfamily
IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
IPR018317	Queuosine synthesis-like
IPR017926	Glutamine amidotransferase type 1
IPR018318	tRNA methyl transferase-like
IPR004739	GMP synthase, N-terminal
IPR006220	Anthranilate synthase component II/delta crystallin
IPR000991	Glutamine amidotransferase class-I, C-terminal
IPR001674	GMP synthase, C-terminal
IPR001317	Carbamoyl phosphate synthase, GATase domain
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL

Publications Open in usermanual
1.	Raushel FM, Thoden JB, Holden HM. The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia. Biochemistry 38 7891-9 1999 [PubMed: 10387030] http://dx.doi.org/10.1021/bi990871p
2.	Tesmer JJ, Klem TJ, Deras ML, Davisson VJ, Smith JL. The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Nat. Struct. Biol. 3 74-86 1996 [PubMed: 8548458] http://dx.doi.org/10.1038/nsb0196-74

InterPro 23.1