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InterPro: IPR001636 SAICAR synthetase

Protein matches Help

UniProtKB

Matches:

1901 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR001636 SAICAR_synt

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01259	SAICAR_synt	1892
PANTHER	PTHR11609	SAICAR_synt	1879
TIGRFAMs	TIGR00081	purC	1446
Signatures in BioMart

InterPro Relationships Help

Children

IPR014106 Phosphoribosylaminoimidazole-succinocarboxamide synthase

Contains

IPR013816 ATP-grasp fold, subdomain 2
IPR018236 SAICAR synthetase, conserved site

GO Term annotation Help

Process

GO:0006164 purine nucleotide biosynthetic process

Function

GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

InterPro annotation

Entry Details in BioMart

Abstract

Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6) (SAICAR synthetase) catalyzes the seventh step in the de novo purine biosynthetic pathway; the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR [1].

In bacteria (purC), fungi (ADE1) and plants (Pur7), SAICAR synthetase is a monofunctional protein; in animals it is the N-terminal domain of a bifunctional enzyme that also catalyse phosphoribosylaminoimidazole carboxylase (AIRC) activity (see IPR000031).

Structural links Help

PDB - click here

SCOP: d.143.1.1

CATH: 3.30.200.20 , 3.30.470.20

Database links Help

PDBe-motif: PS01057 , PS01058

Enzyme: EC:6.3.2.6

PROSITE doc: PDOC00810

PANDIT: PF01259

Blocks: IPB001636

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001636

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P22234 Multifunctional protein ADE2

P27616 Phosphoribosylaminoimidazole-succinocarboxamide synthase

Q10457 Probable multifunctional protein ADE2

Q9DCL9 Multifunctional protein ADE2

Q9I7S8 Multifunctional protein ADE2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000031	1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase
IPR018236	SAICAR synthetase, conserved site
IPR013816	ATP-grasp fold, subdomain 2
IPR001636	SAICAR synthetase
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Zalkin H, Dixon JE. De novo purine nucleotide biosynthesis. Prog. Nucleic Acid Res. Mol. Biol. 42 259-87 1992 [PubMed: 1574589]

Additional Reading Open in usermanual
	Zhang R, Skarina T, Evdokimova E, Edwards A, Savchenko A, Laskowski R, Cuff ME, Joachimiak A. Structure of SAICAR synthase from Thermotoga maritima at 2.2 angstroms reveals an unusual covalent dimer. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 2006 335-9 [PubMed: 16582479] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=16582479
	Levdikov VM, Barynin VV, Grebenko AI, Melik-Adamyan WR, Lamzin VS, Wilson KS. The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis. Structure 6 1998 363-76 [PubMed: 9551557] http://dx.doi.org/10.1016/S0969-2126(98)00038-0
	Ginder ND, Binkowski DJ, Fromm HJ, Honzatko RB. Nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase. J. Biol. Chem. 281 2006 20680-8 [PubMed: 16687397] http://dx.doi.org/10.1074/jbc.M602109200

InterPro 23.1