Mannose-6-phosphate isomerase or phosphomannose isomerase (EC:5.3.1.8) (PMI) is the enzyme that catalyses the interconversion of mannose-6-phosphate and fructose-6-phosphate. In eukaryotes PMI is involved in the synthesis of GDP-mannose, a constituent of N- and O-linked glycans and GPI anchors and in prokaryotes it participates in a variety of pathways, including capsular polysaccharide biosynthesis and D-mannose metabolism. PMI's belong to the cupin superfamily whose functions range from isomerase and epimerase activities involved in the modification of cell wall carbohydrates in bacteria and plants, to non-enzymatic storage proteins in plant seeds, and transcription factors linked to congenital baldness in mammals [1]. Three classes of PMI have been defined [2].
The type II phosphomannose isomerases are bifunctional enzymes EC:5.3.1.8. This entry covers the isomerase region of the protein [3]. The guanosine diphospho-D-mannose pyrophosphorylase region is described in another InterPro entry (see IPR005836).
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