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InterPro: IPR001533 Transcriptional coactivator/pterin dehydratase

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1231 proteins

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Accession

IPR001533 Trans/pterin_deHydtase

Type

Family

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:3.30.1360.20	Trans_pterinDh	1137
Pfam	PF01329	Pterin_4a	1135
PANTHER	PTHR12599	Trans_pterinDh	1144
SuperFamily	SSF55248	Trans_pterinDh	1220
Signatures in BioMart

GO Term annotation Help

Process

GO:0006729 tetrahydrobiopterin biosynthetic process

Function

GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity

InterPro annotation

Entry Details in BioMart

Abstract

DCoH is the dimerisation cofactor of hepatocyte nuclear factor 1 (HNF-1) that functions as both a transcriptional coactivator and a pterin dehydratase [1]. X-ray crystallographic studies have shown that the ligand binds at four sites per tetrameric enzyme, with little apparent conformational change in the protein.

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SCOP: d.74.1.1

CATH: 3.30.1360.20

Database links Help

Enzyme: EC:4.2.1.96

PANDIT: PF01329

Blocks: IPB001533

Taxonomic coverage Help

Example proteins Help

O76454 Pterin-4-alpha-carbinolamine dehydratase

P38744 Putative pterin-4-alpha-carbinolamine dehydratase

P61457 Pterin-4-alpha-carbinolamine dehydratase

Q9CZL5 Pterin-4-alpha-carbinolamine dehydratase 2

Q9TZH6 Putative pterin-4-alpha-carbinolamine dehydratase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR001533	Transcriptional coactivator/pterin dehydratase
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Cronk JD, Endrizzi JA, Alber T. High-resolution structures of the bifunctional enzyme and transcriptional coactivator DCoH and its complex with a product analogue. Protein Sci. 5 1963-72 1996 [PubMed: 8897596] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=8897596

Additional Reading Open in usermanual
	Endrizzi JA, Cronk JD, Wang W, Crabtree GR, Alber T. Crystal structure of DCoH, a bifunctional, protein-binding transcriptional coactivator. Science 268 1995 556-9 [PubMed: 7725101] http://www.sciencemag.org/cgi/content/abstract/268/5210/556
	Rose RB, Bayle JH, Endrizzi JA, Cronk JD, Crabtree GR, Alber T. Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha. Nat. Struct. Biol. 7 2000 744-8 [PubMed: 10966642] http://dx.doi.org/10.1038/78966
	Rose RB, Pullen KE, Bayle JH, Crabtree GR, Alber T. Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2. Biochemistry 43 2004 7345-55 [PubMed: 15182178] http://dx.doi.org/10.1021/bi049620t

InterPro 23.1