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InterPro: IPR001347 Sugar isomerase (SIS)

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UniProtKB

Matches:

10316 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR001347 SIS

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01380	SIS	10316
Signatures in BioMart

InterPro Relationships Help

Found in

IPR004515 Phosphoheptose isomerase, subgroup
IPR004800 KpsF/GutQ
IPR005488 Glucokinase regulatory-like protein
IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising
IPR011857 Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase
IPR014180 Sugar isomerase, AgaS
IPR017552 6-phospho 3-hexuloisomerase
IPR020620 Phosphoheptose isomerase

Contains

IPR005486 Glucokinase regulatory, conserved site

GO Term annotation Help

Process

GO:0005975 carbohydrate metabolic process

Function

GO:0005529 sugar binding

InterPro annotation

Entry Details in BioMart

Abstract

The SIS (Sugar ISomerase) domain is a phosphosugar-binding domain [1] found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars possibly by binding to the end-product of the pathway.

Structural links Help

PDB - click here

SCOP: c.80.1.1 , c.80.1.3

CATH: 3.40.50.10490

Database links Help

PANDIT: PF01380

Blocks: IPB001347

Pfam Clan: CL0067.9

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001347

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A6ZME2 Putative glucosamine--fructose-6-phosphate aminotransferase [isomerizing]

O32157 Fructosamine deglycase frlB

P47856 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1

P72720 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]

Q06210 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000583	Glutamine amidotransferase, class-II
IPR005855	Glucosamine-fructose-6-phosphate aminotransferase, isomerising
IPR001347	Sugar isomerase (SIS)
IPR017932	Glutamine amidotransferase, type II
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Bateman A. The SIS domain: a phosphosugar-binding domain. Trends Biochem. Sci. 24 94-5 1999 [PubMed: 10203754] http://dx.doi.org/10.1016/S0968-0004(99)01357-2

Additional Reading Open in usermanual
	Teplyakov A, Obmolova G, Badet-Denisot MA, Badet B, Polikarpov I. Involvement of the C terminus in intramolecular nitrogen channeling in glucosamine 6-phosphate synthase: evidence from a 1.6 A crystal structure of the isomerase domain. Structure 6 1998 1047-55 [PubMed: 9739095] http://dx.doi.org/10.1016/S0969-2126(98)00105-1
	Mouilleron S, Golinelli-Pimpaneau B. Domain motions of glucosamine-6P synthase: comparison of the anisotropic displacements in the crystals and the catalytic hinge-bending rotation. Protein Sci. 16 2007 485-93 [PubMed: 17322533] http://dx.doi.org/10.1110/ps.062598107
	Keyamura K, Fujikawa N, Ishida T, Ozaki S, Su'etsugu M, Fujimitsu K, Kagawa W, Yokoyama S, Kurumizaka H, Katayama T. The interaction of DiaA and DnaA regulates the replication cycle in E. coli by directly promoting ATP DnaA-specific initiation complexes. Genes Dev. 21 2007 2083-99 [PubMed: 17699754] http://dx.doi.org/10.1101/gad.1561207
	Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS. Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants. J. Biol. Chem. 283 2008 2835-45 [PubMed: 18056714] http://dx.doi.org/10.1074/jbc.M706163200
	Seetharaman J, Rajashankar KR, Solorzano V, Kniewel R, Lima CD, Bonanno JB, Burley SK, Swaminathan S. Crystal structures of two putative phosphoheptose isomerases. Proteins 63 2006 1092-6 [PubMed: 16477602] http://dx.doi.org/10.1002/prot.20908
	Mouilleron S, Badet-Denisot MA, Golinelli-Pimpaneau B. Ordering of C-terminal loop and glutaminase domains of glucosamine-6-phosphate synthase promotes sugar ring opening and formation of the ammonia channel. J. Mol. Biol. 377 2008 1174-85 [PubMed: 18295797] http://dx.doi.org/10.1016/j.jmb.2008.01.077

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