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InterPro: IPR001346 Interferon regulatory factor

Protein matches Help

UniProtKB

Matches:

328 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
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Accession

IPR001346 Interferon_regulatory_factor

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF00605	IRF	315
PRINTS	PR00267	INTFRNREGFCT	283
SMART	SM00348	IRF	320
Signatures in BioMart

InterPro Relationships Help

Parent

IPR011991 Winged helix repressor DNA-binding

Found in

IPR017431 Interferon regulatory factor-1/2

Contains

IPR019817 Interferon regulatory factor, conserved site

GO Term annotation Help

Process

GO:0006355 regulation of transcription, DNA-dependent

Function

GO:0003700 transcription factor activity

InterPro annotation

Entry Details in BioMart

Abstract

The expression of type I interferon genes (interferons alpha and beta) is induced by many agents, including viral attack [1]. Induction is mediated by the binding of interferon regulatory factor 1 (IRF-1) to a region known as the interferon consensus sequence (ICS), located upstream of the interferon genes [2]. Other factors may also bind to the ICS, including IRF-2, which does not function as an activator, but rather suppresses the function of IRF-1 under certain circumstances [3]. IRF proteins contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the ICS; the remaining parts of the sequences vary depending on the precise function of the protein [2].

Structural links Help

PDB - click here

SCOP: a.4.5.23

CATH: 1.10.10.10

Database links Help

PDBe-motif: PS00601

PROSITE doc: PDOC00522

PANDIT: PF00605

Blocks: IPB001346

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001346

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A0FIN4 Interferon regulatory factor 1

P15314 Interferon regulatory factor 1

Q13568 Interferon regulatory factor 5

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019471	Interferon regulatory factor-3
IPR011991	Winged helix repressor DNA-binding
IPR019817	Interferon regulatory factor, conserved site
IPR001346	Interferon regulatory factor
IPR017431	Interferon regulatory factor-1/2
IPR017855	SMAD domain-like
IPR008984	SMAD/FHA domain
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Miyamoto M, Fujita T, Kimura Y, Maruyama M, Harada H, Sudo Y, Miyata T, Taniguchi T. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell 54 903-13 1988 [PubMed: 3409321] http://dx.doi.org/10.1016/S0092-8674(88)91307-4
2.	Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ. Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes. J. Biol. Chem. 267 25589-96 1992 [PubMed: 1460054] http://intl.jbc.org/cgi/reprint/267/35/25589.pdf
3.	Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 58 729-39 1989 [PubMed: 2475256] http://dx.doi.org/10.1016/0092-8674(89)90107-4

Additional Reading Open in usermanual
	Panne D, Maniatis T, Harrison SC. An atomic model of the interferon-beta enhanceosome. Cell 129 2007 1111-23 [PubMed: 17574024] http://dx.doi.org/10.1016/j.cell.2007.05.019
	Panne D, Maniatis T, Harrison SC. Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. EMBO J. 23 2004 4384-93 [PubMed: 15510218] http://dx.doi.org/10.1038/sj.emboj.7600453
	Fujii Y, Shimizu T, Kusumoto M, Kyogoku Y, Taniguchi T, Hakoshima T. Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences. EMBO J. 18 1999 5028-41 [PubMed: 10487755] http://dx.doi.org/10.1093/emboj/18.18.5028
	Escalante CR, Yie J, Thanos D, Aggarwal AK. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation. Nature 391 1998 103-6 [PubMed: 9422515] http://dx.doi.org/10.1038/34224
	Escalante CR, Nistal-Villan E, Shen L, Garcia-Sastre A, Aggarwal AK. Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer. Mol. Cell 26 2007 703-16 [PubMed: 17560375] http://dx.doi.org/10.1016/j.molcel.2007.04.022

InterPro 23.1