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InterPro: IPR001171 Ergosterol biosynthesis ERG4/ERG24

Protein matches Help

UniProtKB

Matches:

484 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR001171 Ergosterol_biosynth_ERG4_ERG24

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01222	ERG4_ERG24	484
Signatures in BioMart

InterPro Relationships Help

Contains

IPR018083 Sterol reductase, conserved site

GO Term annotation Help

Component

GO:0016020 membrane

InterPro annotation

Entry Details in BioMart

Abstract

The two fungal enzymes, C-14 sterol reductase (gene ERG24 in budding yeast and erg3 in Neurospora crassa) and C-24(28) sterol reductase (gene ERG4 in budding yeast and sts1 in fission yeast), are involved in ergosterol biosynthesis. They act by reducing double bonds in precursors of ergosterol [1]. These proteins are highly hydrophobic and seem to contain seven or eight transmembrane regions. Chicken lamin B receptor that is thought to anchor the lamina to the inner nuclear membrane belongs to this family.

Database links Help

PDBe-motif: PS01017 , PS01018

PROSITE doc: PDOC00780

PANDIT: PF01222

Blocks: IPB001171

Pfam Clan: CL0115.8

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001171

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O88455 7-dehydrocholesterol reductase

P25340 Delta(24(24(1)))-sterol reductase

Q14739 Lamin-B receptor

Q8MLV1 Lamin-B receptor

Q9LDR4 Delta(14)-sterol reductase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019023	Lamin-B receptor of TUDOR domain
IPR002999	Tudor domain
IPR018083	Sterol reductase, conserved site
IPR001171	Ergosterol biosynthesis ERG4/ERG24
	PDB Chain
	ModBase
	SCOP Domain

Publications Open in usermanual
1.	Lai MH, Bard M, Pierson CA, Alexander JF, Goebl M, Carter GT, Kirsch DR. The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway. Gene 140 41-9 1994 [PubMed: 8125337] http://dx.doi.org/10.1016/0378-1119(94)90728-5

InterPro 23.1