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InterPro: IPR001057 Glutamate 5-kinase

Protein matches Help

UniProtKB

Matches:

2493 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR001057 Glu_5kinase

Type

Domain

Signatures Help

Database	ID	Name	Proteins
PRINTS	PR00474	GLU5KINASE	2493
Signatures in BioMart

InterPro Relationships Help

Parent

IPR001048 Aspartate/glutamate/uridylate kinase

Found in

IPR005715 Glutamate 5-kinase, ProB-related
IPR011529 Glutamate 5-kinase, pro-B

Contains

IPR019797 Glutamate 5-kinase, conserved site

GO Term annotation Help

Process

GO:0006561 proline biosynthetic process

Function

GO:0004349 glutamate 5-kinase activity

InterPro annotation

Entry Details in BioMart

Abstract

Synonym(s): Gamma-glutamyl kinase

Glutamate 5-kinase (EC:2.7.2.11) catalyses the first step in the biosynthesis of proline, the ATP-dependent phosphorylation of glutamate to glutamate 5-phosphate [1, 2]. It belongs to the larger family of aspartokinases.

Structural links Help

PDB - click here

SCOP: c.73.1.2 , c.73.1.3

Database links Help

PDBe-motif: PS00902

Enzyme: EC:2.7.2

PROSITE doc: PDOC00701

Blocks: IPB001057

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001057

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P32264 Glutamate 5-kinase

P54886 Delta-1-pyrroline-5-carboxylate synthetase

P54887 Delta-1-pyrroline-5-carboxylate synthetase A

P54889 Probable delta-1-pyrroline-5-carboxylate synthetase

Q9Z110 Delta-1-pyrroline-5-carboxylate synthetase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR015947	Pseudouridine synthase/archaeosine transglycosylase-like
IPR005715	Glutamate 5-kinase, ProB-related
IPR000965	Gamma-glutamyl phosphate reductase GPR
IPR016163	Aldehyde dehydrogenase, C-terminal
IPR016162	Aldehyde dehydrogenase, N-terminal
IPR016161	Aldehyde/histidinol dehydrogenase
IPR002478	Pseudouridine synthase/archaeosine transglycosylase
IPR019797	Glutamate 5-kinase, conserved site
IPR005766	Delta l-pyrroline-5-carboxylate synthetase
IPR020593	Gamma-glutamyl phosphate reductase GPR, conserved site
IPR011529	Glutamate 5-kinase, pro-B
IPR001057	Glutamate 5-kinase
IPR001048	Aspartate/glutamate/uridylate kinase
	PDB Chain
	ModBase
	SWISS-MODEL

Publications Open in usermanual
1.	Li W, Brandriss MC. Proline biosynthesis in Saccharomyces cerevisiae: molecular analysis of the PRO1 gene, which encodes gamma-glutamyl kinase. J. Bacteriol. 174 4148-56 1992 [PubMed: 1350780] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=1350780&action=stream&blobtype=pdf
2.	Ogura M, Kawata-Mukai M, Itaya M, Takio K, Tanaka T. Multiple copies of the proB gene enhance degS-dependent extracellular protease production in Bacillus subtilis. J. Bacteriol. 176 5673-80 1994 [PubMed: 8083159] http://jb.asm.org/cgi/content/abstract/176/18/5673

Additional Reading Open in usermanual
	Ramon-Maiques S, Fernandez-Murga ML, Gil-Ortiz F, Vagin A, Fita I, Rubio V. Structural bases of feed-back control of arginine biosynthesis, revealed by the structures of two hexameric N-acetylglutamate kinases, from Thermotoga maritima and Pseudomonas aeruginosa. J. Mol. Biol. 356 2006 695-713 [PubMed: 16376937] http://dx.doi.org/10.1016/j.jmb.2005.11.079
	Fernandez-Murga ML, Ramon-Maiques S, Gil-Ortiz F, Fita I, Rubio V. Towards structural understanding of feedback control of arginine biosynthesis: cloning and expression of the gene for the arginine-inhibited N-acetyl-L-glutamate kinase from Pseudomonas aeruginosa, purification and crystallization of the recombinant enzyme and preliminary X-ray studies. Acta Crystallogr. D Biol. Crystallogr. 58 2002 1045-7 [PubMed: 12037312] http://dx.doi.org/10.1107/S0907444902005243

InterPro 23.1