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InterPro: IPR001016 RNA-dependent RNA polymerase, L protein, viral

Protein matches Help

UniProtKB

Matches:

695 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR001016 RNA_pol_L_viral

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF00946	Paramyx_RNA_pol	695
Signatures in BioMart

InterPro Relationships Help

Children

IPR016269 RNA-directed RNA polymerase, paramyxovirus
IPR017234 RNA-directed RNA polymerase, rhabdovirus
IPR017235 RNA-directed RNA polymerase, filovirus

Contains

IPR014023 RNA-directed RNA polymerase catalytic

GO Term annotation Help

Process

GO:0006350 transcription

Function

GO:0003723 RNA binding
GO:0003968 RNA-directed RNA polymerase activity

InterPro annotation

Entry Details in BioMart

Abstract

Paramyxoviridae, like other non-segmented negative strand RNA viruses, have an RNA-dependent RNA polymerase composed of two subunits, a large protein L and a phosphoprotein P. The L protein confers the RNA polymerase activity on the complex while the P protein acts as a transcription factor [1].

Database links Help

Enzyme: EC:2.1.1.56 , EC:2.7.7.48

PANDIT: PF00946

Blocks: IPB001016

CluSTr: ALLvsALL:1994:40.7

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001016

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A3F5L9 Large structural protein

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR001016	RNA-dependent RNA polymerase, L protein, viral
IPR014023	RNA-directed RNA polymerase catalytic
IPR017234	RNA-directed RNA polymerase, rhabdovirus

Publications Open in usermanual
1.	De BP, Das T, Banerjee AK. Role of cellular kinases in the gene expression of nonsegmented negative strand RNA viruses. Biol. Chem. 378 489-93 1997 [PubMed: 9224928]

Additional Reading Open in usermanual
	Banerjee AK, Barik S, De BP. Gene expression of nonsegmented negative strand RNA viruses. Pharmacol. Ther. 51 1991 47-70 [PubMed: 1771177] http://dx.doi.org/10.1016/0163-7258(91)90041-J

InterPro 23.1