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InterPro: IPR001005 SANT, DNA-binding

Protein matches Help

UniProtKB

Matches:

8549 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR001005 SANT_DNA-bd

Type

Domain

Signatures Help

Database	ID	Name	Proteins
SMART	SM00717	SANT	8549
Signatures in BioMart

InterPro Relationships Help

Parent

IPR012287 Homeodomain-related

Children

IPR017877 MYB-like
IPR017884 SANT, eukarya

Found in

IPR015495 Myb transcription factor
IPR016310 Transcription factor, GAMYB
IPR017174 Transcription factor IIIB, Bdp1 subunit, fungi
IPR017357 Telomeric repeat-binding factor 1, Pin2
IPR017930 HTH transcriptional regulator, Myb-type, DNA-binding

Contains

IPR006447 Myb-like DNA-binding domain, SHAQKYF class
IPR015195 SLIDE

GO Term annotation Help

Function

GO:0003677 DNA binding

InterPro annotation

Entry Details in BioMart

Abstract

The retroviral oncogene v-myb, and its cellular counterpart c-myb, encode nuclear DNA-binding proteins. These belong to the SANT domain family that specifically recognise the sequence YAAC(G/T)G [1, 2]. In myb, one of the most conserved regions consisting of three tandem repeats has been shown to be involved in DNA-binding [3].

Structural links Help

PDB - click here

SCOP: a.187.1.1 , a.4.1.1 , a.4.1.13 , a.4.1.3 , a.4.1.4 , a.4.1.6

CATH: 1.10.10.60

Database links Help

PDBe-motif: PS00037 , PS00334

PROSITE doc: PDOC00037

Blocks: IPB001005

Interactions Help

This domain has been experimentally proven to be involved in Protein:Protein interactions.
Representative data is shown with the following example proteins:

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001005

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O75376 Nuclear receptor corepressor 1

P06876 Myb proto-oncogene protein

P11938 DNA-binding protein RAP1

P34333 Gex-3-interacting protein 8

Q24368 Chromatin-remodeling complex ATPase chain Iswi

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR014778	Myb, DNA-binding
IPR015495	Myb transcription factor
IPR015195	SLIDE
IPR012287	Homeodomain-related
IPR017930	HTH transcriptional regulator, Myb-type, DNA-binding
IPR014021	Helicase, superfamily 1/2, ATP-binding domain
IPR015395	C-myb, C-terminal
IPR015194	ATPase, nucleosome remodelling ISWI, HAND domain
IPR012642	Transcriptional regulator, Wos2-domain
IPR015280	Rap1, DNA-binding
IPR001650	DNA/RNA helicase, C-terminal
IPR001005	SANT, DNA-binding
IPR017877	MYB-like
IPR001357	BRCT
IPR014001	DEAD-like helicase, N-terminal
IPR017884	SANT, eukarya
IPR000330	SNF2-related
IPR009057	Homeodomain-like
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Biedenkapp H, Borgmeyer U, Sippel AE, Klempnauer KH. Viral myb oncogene encodes a sequence-specific DNA-binding activity. Nature 335 835-7 1988 [PubMed: 3185713] http://dx.doi.org/10.1038/335835a0
2.	Aasland R, Stewart AF, Gibson T. The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB. Trends Biochem. Sci. 21 87-8 1996 [PubMed: 8882580] http://dx.doi.org/10.1016/0968-0004(96)30009-1
3.	Klempnauer KH, Sippel AE. The highly conserved amino-terminal region of the protein encoded by the v-myb oncogene functions as a DNA-binding domain. EMBO J. 6 2719-25 1987 [PubMed: 2824190] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=2824190

Additional Reading Open in usermanual
	Sohn DH, Lee KY, Lee C, Oh J, Chung H, Jeon SH, Seong RH. SRG3 interacts directly with the major components of the SWI/SNF chromatin remodeling complex and protects them from proteasomal degradation. J. Biol. Chem. 282 2007 10614-24 [PubMed: 17255092] http://dx.doi.org/10.1074/jbc.M610563200
	Sue SC, Hsiao HH, Chung BC, Cheng YH, Hsueh KL, Chen CM, Ho CH, Huang TH. Solution structure of the Arabidopsis thaliana telomeric repeat-binding protein DNA binding domain: a new fold with an additional C-terminal helix. J. Mol. Biol. 356 2006 72-85 [PubMed: 16337232] http://dx.doi.org/10.1016/j.jmb.2005.11.009
	Yang M, Culhane JC, Szewczuk LM, Gocke CB, Brautigam CA, Tomchick DR, Machius M, Cole PA, Yu H. Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat. Struct. Mol. Biol. 14 2007 535-9 [PubMed: 17529991] http://dx.doi.org/10.1038/nsmb1255
	Stevenson CE, Burton N, Costa MM, Nath U, Dixon RA, Coen ES, Lawson DM. Crystal structure of the MYB domain of the RAD transcription factor from Antirrhinum majus. Proteins 65 2006 1041-5 [PubMed: 17044043] http://dx.doi.org/10.1002/prot.21136
	Choi K, Park C, Lee J, Oh M, Noh B, Lee I. Arabidopsis homologs of components of the SWR1 complex regulate flowering and plant development. Development 134 2007 1931-41 [PubMed: 17470967] http://dx.doi.org/10.1242/dev.001891
	Yoneyama M, Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Watanabe S, Tomo Y, Nishimura Y, Harada T, Terada T, Shirouzu M, Hayashizaki Y, Ohara O, Tanaka A, Kigawa T, Yokoyama S. Structural and functional differences of SWIRM domain subtypes. J. Mol. Biol. 369 2007 222-38 [PubMed: 17428495] http://dx.doi.org/10.1016/j.jmb.2007.03.027
	Ko S, Jun SH, Bae H, Byun JS, Han W, Park H, Yang SW, Park SY, Jeon YH, Cheong C, Kim WT, Lee W, Cho HS. Structure of the DNA-binding domain of NgTRF1 reveals unique features of plant telomere-binding proteins. Nucleic Acids Res. 36 2008 2739-55 [PubMed: 18367475] http://dx.doi.org/10.1093/nar/gkn030

InterPro 23.1