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InterPro: IPR000922 D-galactoside/L-rhamnose binding SUEL lectin

Protein matches Help

UniProtKB

Matches:

554 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR000922 Lectin_gal_bd

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02140	Gal_Lectin	533
PROSITE profile	PS50228	SUEL_LECTIN	547
Signatures in BioMart

InterPro Relationships Help

Found in

IPR003924 GPCR, family 2, latrophilin

GO Term annotation Help

Function

GO:0005529 sugar binding

InterPro annotation

Entry Details in BioMart

Abstract

The D-galactoside binding lectin purified from sea urchin (Anthocidaris crassispina) eggs exists as a disulphide-linked homodimer of two subunits; the dimeric form is essential for hemagglutination activity [1]. The sea urchin egg lectin (SUEL) forms a new class of lectins. Although SUEL was first isolated as a D-galactoside binding lectin, it was latter shown that it bind to L-rhamnose preferentially [1, 2]. L-rhamnose and D-galactose share the same hydroxyl group orientation at C2 and C4 of the pyranose ring structure.

A cysteine-rich domain homologous to the SUEL protein has been identified in the following proteins [3, 4, 5]:

Plant beta-galactosidases (EC:3.2.1.23) (lactases).
Mammalian latrophilin, the calcium independent receptor of alpha-latrotoxin (CIRL). The galactose-binding lectin domain is not required for alpha-latratoxin binding [5].
Human lectomedin-1.
Rhamnose-binding lectin (SAL) from catfish (Silurus asotus, Namazu) eggs. This protein is composed of three tandem repeat domains homologous to the SUEL lectin domain. All cysteine positions of each domain are completely conserved [2].
The hypothetical B0457.1, F32A7.3A and F32A7.3B proteins from Caenorhabditis elegans.
The human KIAA0821 protein.

Database links Help

PROSITE doc: PDOC50228

PANDIT: PF02140

Blocks: IPB000922

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR000922

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O94910 Latrophilin-1

P86179 L-rhamnose-binding lectin CSL3

Q0INM3 Beta-galactosidase 15

Q80TR1 Latrophilin-1

Q8GX69 Beta-galactosidase 16

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR017983	GPCR, family 2, secretin-like, conserved site
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR003112	Olfactomedin-like
IPR000832	GPCR, family 2, secretin-like
IPR017981	GPCR, family 2-like
IPR000203	GPS domain
IPR001944	Glycoside hydrolase, family 35
IPR008979	Galactose-binding domain-like
IPR003334	GPCR, family 2, latrophilin, C-terminal
IPR000922	D-galactoside/L-rhamnose binding SUEL lectin
IPR017853	Glycoside hydrolase, catalytic core
IPR003924	GPCR, family 2, latrophilin
IPR019801	Glycoside hydrolase, family 35, conserved site
IPR001879	GPCR, family 2, extracellular hormone receptor domain
	PDB Chain
	ModBase
	SWISS-MODEL

Publications Open in usermanual
1.	Ozeki Y, Matsui T, Suzuki M, Titani K. Amino acid sequence and molecular characterization of a D-galactoside-specific lectin purified from sea urchin (Anthocidaris crassispina) eggs. Biochemistry 30 2391-4 1991 [PubMed: 2001368] http://dx.doi.org/10.1021/bi00223a014
2.	Hosono M, Ishikawa K, Mineki R, Murayama K, Numata C, Ogawa Y, Takayanagi Y, Nitta K. Tandem repeat structure of rhamnose-binding lectin from catfish (Silurus asotus) eggs. Biochim. Biophys. Acta 1472 668-75 1999 [PubMed: 10564781] http://dx.doi.org/10.1016/S0304-4165(99)00185-3
3.	Lelianova VG, Davletov BA, Sterling A, Rahman MA, Grishin EV, Totty NF, Ushkaryov YA. Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. J. Biol. Chem. 272 21504-8 1997 [PubMed: 9261169] http://dx.doi.org/10.1074/jbc.272.34.21504
4.	Tateno H, Saneyoshi A, Ogawa T, Muramoto K, Kamiya H, Saneyoshi M. Isolation and characterization of rhamnose-binding lectins from eggs of steelhead trout (Oncorhynchus mykiss) homologous to low density lipoprotein receptor superfamily. J. Biol. Chem. 273 19190-7 1998 [PubMed: 9668106] http://dx.doi.org/10.1074/jbc.273.30.19190
5.	Krasnoperov V, Bittner MA, Holz RW, Chepurny O, Petrenko AG. Structural requirements for alpha-latrotoxin binding and alpha-latrotoxin-stimulated secretion. A study with calcium-independent receptor of alpha-latrotoxin (CIRL) deletion mutants. J. Biol. Chem. 274 3590-6 1999 [PubMed: 9920906] http://dx.doi.org/10.1074/jbc.274.6.3590

InterPro 23.1