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InterPro: IPR000903 Myristoyl-CoA:protein N-myristoyltransferase

Protein matches Help

UniProtKB

Matches:

241 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR000903 Myristoyl_trans

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01233	NMT	222
Pfam	PF02799	NMT_C	224
PIRSF	PIRSF015892	N-myristl_transf	204
PROSITE pattern	PS00975	NMT_1	183
PROSITE pattern	PS00976	NMT_2	192
PANTHER	PTHR11377	Myristoyl_trans	237
Signatures in BioMart

InterPro Relationships Help

Contains

IPR016181 Acyl-CoA N-acyltransferase

GO Term annotation Help

Process

GO:0006499 N-terminal protein myristoylation

Function

GO:0004379 glycylpeptide N-tetradecanoyltransferase activity

InterPro annotation

Entry Details in BioMart

Abstract

Myristoyl-CoA:protein N-myristoyltransferase (EC:2.3.1.97) (Nmt) [1] is the enzyme responsible for transferring a myristate group on the N-terminal glycine of a number of cellular eukaryotics and viral proteins. Nmt is a monomeric protein of about 50 to 60kDa whose sequence appears to be well conserved.

Structural links Help

PDB - click here

SCOP: d.108.1.2

CATH: 3.40.630.30

Database links Help

PDBe-motif: PS00975 , PS00976

Enzyme: EC:2.3.1.97

PROSITE doc: PDOC00752

PANDIT: PF01233 , PF02799

Blocks: IPB000903

CluSTr: ALLvsALL:6573:44.7

Pfam Clan: CL0257.5

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR000903

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O61613 Glycylpeptide N-tetradecanoyltransferase

O70310 Glycylpeptide N-tetradecanoyltransferase 1

P14743 Glycylpeptide N-tetradecanoyltransferase

P30419 Glycylpeptide N-tetradecanoyltransferase 1

P46548 Probable glycylpeptide N-tetradecanoyltransferase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000903	Myristoyl-CoA:protein N-myristoyltransferase
IPR016181	Acyl-CoA N-acyltransferase
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Rudnick DA, McWherter CA, Gokel GW, Gordon JI. MyristoylCoA:protein N-myristoyltransferase. Adv. Enzymol. Relat. Areas Mol. Biol. 67 375-430 1993 [PubMed: 8322618]

Additional Reading Open in usermanual
	Farazi TA, Waksman G, Gordon JI. Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis. Biochemistry 40 2001 6335-43 [PubMed: 11371195] http://dx.doi.org/10.1021/bi0101401
	Weston SA, Camble R, Colls J, Rosenbrock G, Taylor I, Egerton M, Tucker AD, Tunnicliffe A, Mistry A, Mancia F, de la Fortelle E, Irwin J, Bricogne G, Pauptit RA. Crystal structure of the anti-fungal target N-myristoyl transferase. Nat. Struct. Biol. 5 1998 213-21 [PubMed: 9501915] http://dx.doi.org/10.1038/nsb0398-213
	Sogabe S, Masubuchi M, Sakata K, Fukami TA, Morikami K, Shiratori Y, Ebiike H, Kawasaki K, Aoki Y, Shimma N, D'Arcy A, Winkler FK, Banner DW, Ohtsuka T. Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors. Chem. Biol. 9 2002 1119-28 [PubMed: 12401496] http://dx.doi.org/10.1016/S1074-5521(02)00240-5
	Bhatnagar RS, Futterer K, Farazi TA, Korolev S, Murray CL, Jackson-Machelski E, Gokel GW, Gordon JI, Waksman G. Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs. Nat. Struct. Biol. 5 1998 1091-7 [PubMed: 9846880] http://dx.doi.org/10.1038/4202

InterPro 23.1