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InterPro: IPR000777 Envelope glycoprotein GP120

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UniProtKB

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98831 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR000777 GP120

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:2.170.40.20	GP120	86574
Pfam	PF00516	GP120	98824
SuperFamily	SSF56502	GP120	94105
Signatures in BioMart

GO Term annotation Help

Component

GO:0019031 viral envelope

InterPro annotation

Entry Details in BioMart

Abstract

The entry of HIV requires interaction of viral GP120, an envelope glycoprotein with human T-cell surface glycoprotein CD4 and a chemokine receptor on the cell surface. These envelope glycoproteins are found in HIV types 1 and 2, and Simian Immunodeficiency virus (SIV).

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SCOP: d.172.1.1 , j.53.1.1

CATH: 2.170.40.20

Database links Help

PANDIT: PF00516

Taxonomic coverage Help

Example proteins Help

P03375 Envelope glycoprotein gp160

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000328	Envelope Polyprotein GP41
IPR000777	Envelope glycoprotein GP120
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Help

Additional Reading Open in usermanual
	Huang CC, Stricher F, Martin L, Decker JM, Majeed S, Barthe P, Hendrickson WA, Robinson J, Roumestand C, Sodroski J, Wyatt R, Shaw GM, Vita C, Kwong PD. Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth. Structure 13 2005 755-68 [PubMed: 15893666] http://dx.doi.org/10.1016/j.str.2005.03.006
	Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC. Structure of an unliganded simian immunodeficiency virus gp120 core. Nature 433 2005 834-41 [PubMed: 15729334] http://dx.doi.org/10.1038/nature03327
	Stricher F, Huang CC, Descours A, Duquesnoy S, Combes O, Decker JM, Kwon YD, Lusso P, Shaw GM, Vita C, Kwong PD, Martin L. Combinatorial optimization of a CD4-mimetic miniprotein and cocrystal structures with HIV-1 gp120 envelope glycoprotein. J. Mol. Biol. 382 2008 510-24 [PubMed: 18619974] http://dx.doi.org/10.1016/j.jmb.2008.06.069
	Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski J, Wyatt R, Nabel GJ, Kwong PD. Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature 445 2007 732-7 [PubMed: 17301785] http://dx.doi.org/10.1038/nature05580
	Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393 1998 648-59 [PubMed: 9641677] http://dx.doi.org/10.1038/31405
	Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, Wyatt R, Kwong PD. Structure of a V3-containing HIV-1 gp120 core. Science 310 2005 1025-8 [PubMed: 16284180] http://dx.doi.org/10.1126/science.1118398

InterPro 23.1