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InterPro: IPR000732 Rhodopsin

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UniProtKB

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2685 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
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Accession

IPR000732 Rhodopsin

Type

Family

Signatures Help

Database	ID	Name	Proteins
PRINTS	PR00579	RHODOPSIN	2685
Signatures in BioMart

InterPro Relationships Help

Parent

IPR001760 Opsin

Contains

IPR019477 Rhodopsin, N-terminal

GO Term annotation Help

Process

GO:0007186 G-protein coupled receptor protein signaling pathway
GO:0007602 phototransduction

Component

GO:0016021 integral to membrane

InterPro annotation

Entry Details in BioMart

Abstract

The photoreceptor rhodopsin is a complex of the vision protein opsin and the chromophore 11-cis-retinal (derived from vitamin A) [1]. Light-sensitive pigments occur in both the rod cells (black and white vision) and cone cells (colour vision) in the retina at the back of the eye. Although related, the differences in sequence between the opsins accounts for their differences in absorption: rhodopsin in rod cells, and blue, red, and green opsins in cone cells. Upon exposure to light, the 11-cis-retinal attached to rod or cone opsin isomerises to all-trans-retinal, which leads to the activation of the G protein transducin, and ultimately to the hyperpolarisation of the cell and the propagation of a nerve impulse that is perceived as light.

This entry represents opsins found in rhodopsins, as well as blue-sensitive opsin and green-sensitive opsin.

Structural links Help

PDB - click here

SCOP: f.13.1.2 , j.35.1.1

CATH: 1.20.1070.10 , 4.10.840.10

Database links Help

Blocks: IPB000732

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR000732

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P02699 Rhodopsin

P08100 Rhodopsin

P15409 Rhodopsin

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000276	7TM GPCR, rhodopsin-like
IPR019477	Rhodopsin, N-terminal
IPR017452	GPCR, rhodopsin-like superfamily
IPR000732	Rhodopsin
IPR001760	Opsin
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Watson S, Arkinstall S. Opsins. 214-22 1994

Additional Reading Open in usermanual
	Schreiber M, Sugihara M, Okada T, Buss V. Quantum mechanical studies on the crystallographic model of bathorhodopsin. Angew. Chem. Int. Ed. Engl. 45 2006 4274-7 [PubMed: 16729349] http://dx.doi.org/10.1002/anie.200600585
	Nakamichi H, Okada T. Crystallographic analysis of primary visual photochemistry. Angew. Chem. Int. Ed. Engl. 45 2006 4270-3 [PubMed: 16586416] http://dx.doi.org/10.1002/anie.200600595
	Nakamichi H, Buss V, Okada T. Photoisomerization mechanism of rhodopsin and 9-cis-rhodopsin revealed by x-ray crystallography. Biophys. J. 92 2007 L106-8 [PubMed: 17449675] http://dx.doi.org/10.1529/biophysj.107.108225
	Sekharan S, Sugihara M, Weingart O, Okada T, Buss V. Protein assistance in the photoisomerization of rhodopsin and 9-cis-rhodopsin--insights from experiment and theory. J. Am. Chem. Soc. 129 2007 1052-4 [PubMed: 17263385] http://dx.doi.org/10.1021/ja066970p
	Applebury ML, Hargrave PA. Molecular biology of the visual pigments. Vision Res. 26 1986 1881-95 [PubMed: 3303660] http://dx.doi.org/10.1016/0042-6989(86)90115-X
	Attwood TK, Findlay JB. Fingerprinting G-protein-coupled receptors. Protein Eng. 7 1994 195-203 [PubMed: 8170923] http://dx.doi.org/10.1093/protein/7.2.195
	Standfuss J, Xie G, Edwards PC, Burghammer M, Oprian DD, Schertler GF. Crystal structure of a thermally stable rhodopsin mutant. J. Mol. Biol. 372 2007 1179-88 [PubMed: 17825322] http://dx.doi.org/10.1016/j.jmb.2007.03.007
	Attwood TK, Findlay JB. Design of a discriminating fingerprint for G-protein-coupled receptors. Protein Eng. 6 1993 167-76 [PubMed: 8386361] http://dx.doi.org/10.1093/protein/6.2.167
	Fryxell KJ, Meyerowitz EM. The evolution of rhodopsins and neurotransmitter receptors. J. Mol. Evol. 33 1991 367-78 [PubMed: 1663559] http://dx.doi.org/10.1007/BF02102867

InterPro 24.0