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InterPro: IPR000728 AIR synthase related protein

Protein matches Help

UniProtKB

Matches:

6007 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR000728 AIR_synth

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF00586	AIRS	6007
Signatures in BioMart

InterPro Relationships Help

Parent

IPR016188 PurM, N-terminal-like

Found in

IPR004536 Selenide water dikinase
IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase
IPR006283 Thiamine-monophosphate kinase
IPR009186 Predicted nickel metalloenzyme maturation factor, AIR synthase-related
IPR010073 Phosphoribosylformylglycinamidine synthase, eukaryote/proteobacteria
IPR010074 Phosphoribosylformylglycinamidine synthase II
IPR010141 Phosphoribosylformylglycinamidine synthase, FGAM
IPR011413 Uncharacterised conserved protein UCP036540
IPR011414 Uncharacterised conserved protein UCP036541
IPR011854 Hydrogenase expression/formation protein HypE
IPR017668 Putative methanogenesis marker protein 2

GO Term annotation Help

Function

GO:0003824 catalytic activity

InterPro annotation

Entry Details in BioMart

Abstract

This family includes Hydrogen expression/formation protein, HypE, which may be involved in the maturation of NifE hydrogenase; AIR synthase and FGAM synthase, which are involved in de novo purine biosynthesis; and selenide, water dikinase, an enzyme which synthesizes selenophosphate from selenide and ATP.

Structural links Help

PDB - click here

SCOP: d.79.4.1

CATH: 3.30.1330.10

Database links Help

Enzyme: EC:6.3

PANDIT: PF00586

Blocks: IPB000728

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR000728

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O18373 Selenide, water dikinase

O62461 Probable selenide, water dikinase

P07244 Bifunctional purine biosynthetic protein ADE5,7

P22102 Trifunctional purine biosynthetic protein adenosine-3

P97364 Selenide, water dikinase 2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013815	ATP-grasp fold, subdomain 1
IPR013816	ATP-grasp fold, subdomain 2
IPR002376	Formyl transferase, N-terminal
IPR013817	Pre-ATP-grasp fold
IPR020559	Phosphoribosylglycinamide synthetase, conserved site
IPR004607	Phosphoribosylglycinamide formyltransferase
IPR016188	PurM, N-terminal-like
IPR016185	PreATP-grasp-like fold
IPR011761	ATP-grasp fold
IPR001555	Phosphoribosylglycinamide formyltransferase, active site
IPR004733	Phosphoribosylformylglycinamidine cyclo-ligase
IPR011054	Rudiment single hybrid motif
IPR010918	AIR synthase related protein, C-terminal
IPR020561	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
IPR020560	Phosphoribosylglycinamide synthetase, C-domain
IPR004536	Selenide water dikinase
IPR020562	Phosphoribosylglycinamide synthetase, N-domain
IPR000728	AIR synthase related protein
IPR000115	Phosphoribosylglycinamide synthetase
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Morar M, Hoskins AA, Stubbe J, Ealick SE. Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation. Biochemistry 47 2008 7816-30 [PubMed: 18597481] http://dx.doi.org/10.1021/bi800329p
	McCulloch KM, Kinsland C, Begley TP, Ealick SE. Structural studies of thiamin monophosphate kinase in complex with substrates and products. Biochemistry 47 2008 3810-21 [PubMed: 18311927] http://dx.doi.org/10.1021/bi800041h
	Matsumoto E, Sekine SI, Akasaka R, Otta Y, Katsura K, Inoue M, Kaminishi T, Terada T, Shirouzu M, Yokoyama S. Structure of an N-terminally truncated selenophosphate synthetase from Aquifex aeolicus. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 2008 453-8 [PubMed: 18540050]
	Watanabe S, Matsumi R, Arai T, Atomi H, Imanaka T, Miki K. Crystal structures of [NiFe] hydrogenase maturation proteins HypC, HypD, and HypE: insights into cyanation reaction by thiol redox signaling. Mol. Cell 27 2007 29-40 [PubMed: 17612488] http://dx.doi.org/10.1016/j.molcel.2007.05.039
	Li C, Kappock TJ, Stubbe J, Weaver TM, Ealick SE. X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution. Structure 7 1999 1155-66 [PubMed: 10508786] http://dx.doi.org/10.1016/S0969-2126(99)80182-8
	Itoh Y, Sekine S, Matsumoto E, Akasaka R, Takemoto C, Shirouzu M, Yokoyama S. Structure of selenophosphate synthetase essential for selenium incorporation into proteins and RNAs. J. Mol. Biol. 385 2009 1456-69 [PubMed: 18773910] http://dx.doi.org/10.1016/j.jmb.2008.08.042

InterPro 23.1