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InterPro: IPR000719 Protein kinase, catalytic domain

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UniProtKB
Matches:
63590 proteins
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IPR000719 Prot_kinase_cat_dom
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Domain
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InterPro RelationshipsHelp
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Parent IPR011009 Protein kinase-like domain
Children IPR001245 Tyrosine-protein kinase, catalytic domain
IPR017442 Serine/threonine-protein kinase-like domain
IPR018934 RIO-like kinase
Found in IPR000239 GPCR kinase
IPR002291 Phosphorylase kinase, gamma catalytic subunit
IPR008790 Poxvirus serinethreonine kinase
IPR009127 Tyrosine-protein kinase, JAK, conserved region
IPR009128 Tyrosine-protein kinase, JAK1
IPR009130 Tyrosine-protein kinase, JAK3
IPR009131 Tyrosine-protein kinase, non-receptor, TYK2
IPR009136 Tyrosine-protein kinase, vascular endothelial growth factor receptor 2 (VEGFR2)
IPR009220 Peptidase M22, O-sialoglycoprotein endopeptidase/protein kinase
IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR013334 Hormonally upregulated Neu-associated kinase
IPR013336 Serine/threonine-protein kinase, Unc-51/Ulk
IPR015515 Protein kinase GCN2
IPR015725 Myosin light chain kinase
IPR015726 Serine/threonine protein kinase, striated muscle-specific
IPR015728 Serine/threonine-protein kinase, Polo-like
IPR015729 Serine/threonine-protein kinase, Checkpoint 1/Hal4
IPR015730 Myosin light chain kinase 2
IPR015731 MAP Kinase Interacting Kinase
IPR015732 Serine/threonine-protein kinase PSKH
IPR015733 Calcium/calmodulin-dependent protein kinase IV
IPR015734 Calcium/calmodulin-dependent protein kinase 1
IPR015735 Serine/threonine-protein kinase STK
IPR015736 Sperm motility kinase
IPR015737 Serine/threonine-protein kinase, testis-specific
IPR015738 Protein kinase, Snf1-like
IPR015739 Maternal embryonic leucine zipper kinase
IPR015740 Serine/threonine-protein kinase-like, plant
IPR015741 Protein kinase, Snf1-like AMPK
IPR015742 Calcium/calmodulin-dependent protein kinase II isoform
IPR015751 Rho-associated coiled-coil containing protein kinase
IPR015772 Tyrosine-protein kinase, non-receptor TNK1
IPR015773 Tyrosine-protein kinase, non-receptor MATK
IPR015774 Tyrosine-protein kinase, non-receptor PTK6
IPR015775 Tyrosine-protein kinase, receptor Axl-related
IPR015777 Tyrosine-protein kinase, Ret receptor-like
IPR015778 Tyrosine-protein kinase, non-receptor Csk
IPR015779 Tyrosine-protein kinase, non-receptor Ack, N-terminal
IPR015780 Tyrosine-protein kinase, epidermal growth factor receptor-related
IPR015781 Tyrosine-protein kinase, angiopoietin receptor
IPR015782 Testis-specific kinase 1
IPR015785 Mitogen activated protein kinase kinase kinase-like
IPR015786 Mitogen activated protein kinase kinase kinase-related
IPR016231 Mitogen-activated protein kinase kinase kinase, 9/10/11
IPR016232 cGMP-dependent protein kinase
IPR016234 Serine/threonine-protein kinase, Sbk1
IPR016235 Tyrosine/threonine-protein kinase, Cdc2 inhibitor
IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2
IPR016240 Serine/threonine-protein kinase YKL116C, predicted
IPR016241 Serine/threonine-protein kinase YKL171W, predicted
IPR016242 Serine/threonine-protein kinase MPS1
IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor
IPR016246 Tyrosine-protein kinase, insulin-like receptor
IPR016247 Tyrosine-protein kinase, receptor ROR, subgroup
IPR016248 Tyrosine-protein kinase, fibroblast growth factor receptor
IPR016250 Tyrosine-protein kinase, non-receptor Fes, subgroup
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR016256 Serine/threonine-protein kinase RAD53
IPR016257 Tyrosine-protein kinase, ephrin receptor
IPR016815 Rhoptry protein, Rop2-like
IPR016960 Uncharacterised conserved protein UCP030823, kinase, HhH DNA-binding
IPR017090 Serine/threonine-protein kinase, SNF1-like
IPR017164 Wee1-like protein kinase
IPR017184 Serine/threonine-protein kinase Unc-51
IPR017193 Anti-muellerian hormone receptor, type II
IPR017239 MAP kinase kinase kinase STE11
IPR017322 Receptor-interacting serine/threonine-protein kinase 2
IPR017348 Proto-oncogene serine/threonine-protein kinase Pim-1
IPR017419 Mitogen-activated protein kinase kinase kinase, 12/13
IPR017424 Mitogen-activated protein kinase kinase kinase 8
IPR017425 Mitogen-activated protein kinase kinase kinase 14
IPR020636 Calcium/calmodulin-dependent protein kinase-like
IPR020640 Serine/threonine-protein kinase, SIK1
IPR020641 Protein kinase, predicted
IPR020642 Calcium-dependent protein kinase
IPR020643 Serine/threonine-protein kinase 2, predicted
IPR020644 Serine/threonine-protein kinase 17
IPR020645 Serine/threonine-protein kinase 33
IPR020646 MAP kinase-activated protein kinase (MAPKAPK)
IPR020647 Meiosis-specific serine/threonine-protein kinase Mek1
IPR020648 Serine/threonine-protein kinase Chk2
IPR020649 Serine/threonine-protein kinase DCLK
IPR020650 Calcium/calmodulin-dependent protein kinase type II
IPR020651 Calcium/calmodulin-dependent protein kinase CMK
IPR020654 CaM kinase-like vesicle-associated protein
IPR020655 Serine/threonine-protein kinase, putative
IPR020656 Serine/threonine-protein kinase ATG1
IPR020657 Calcium/calmodulin-dependent protein kinase kinase
IPR020658 Serine/threonine-protein kinase, AMPK-related
IPR020660 CBL-interacting protein kinase
IPR020661 SNF-related serine/threonine-protein kinase, SNRK
IPR020662 Serine/threonine-protein kinase ipl1
IPR020663 Spindle assembly checkpoint kinase
IPR020664 Serine/threonine-protein kinase PLK4
IPR020665 SNF1-like kinase, NUAK-type
IPR020666 Serine/threonine-protein kinase KIN-29
IPR020668 Serine/threonine-protein kinase NIM1
IPR020669 MAP/microtubule affinity-regulating kinase 3
IPR020670 MAP/microtubule affinity-regulating kinase 1/2/4
IPR020671 BR serine/threonine-protein kinase
IPR020673 Serine/threonine-protein kinase KIN1/2
IPR020674 Serine/threonine-protein kinase KIN4-related
IPR020675 Myosin light chain kinase-related
IPR020676 Death-associated protein kinase
IPR020677 Serine/threonine-protein kinase Y2666, predicted
IPR020679 Serine/threonine-protein kinase YMR291W, predicted
IPR020682 Obscurin/Myosin light chain kinase
IPR020684 Rho-associated coiled-coil containing protein kinase-like
IPR020685 Tyrosine-protein kinase
IPR020686 Tyrosine-protein kinase, non-receptor ZAP-70
IPR020688 Tyrosine-protein kinase, receptor Let-23
IPR020689 Tyrosine-protein kinase, EGF receptor, fish
IPR020690 Tyrosine-protein kinase, receptor erbB-4
IPR020691 Tyrosine-protein kinase, receptor erbB-3, fish
IPR020692 Tyrosine-protein kinase, receptor erbB-3
IPR020693 Tyrosine-protein kinase, non-receptor Jak2
IPR020694 Tyrosine-protein kinase, ephrin receptor, subgroup
IPR020695 Tyrosine-protein kinase, receptor STYK1
IPR020696 Tyrosine-protein kinase, receptor Tie-1
IPR020697 Tyrosine-protein kinase, non-receptor ITK/TSK
IPR020698 Tyrosine-protein kinase, non-receptor Btk29A
IPR020699 Tyrosine-protein kinase, non-receptor Srms
IPR020700 Tyrosine-protein kinase, non-receptor Abl
IPR020701 Tyrosine-protein kinase, non-receptor Src-1, nematode
IPR020702 Tyrosine-protein kinase, non-receptor FRK
IPR020703 Tyrosine-protein kinase, non-receptor Src64B
IPR020704 Tyrosine-protein kinase, receptor TYRO3, Zebrafish
IPR020705 Tyrosine-protein kinase, receptor MER
IPR020706 Tyrosine-protein kinase, receptor SEA
IPR020707 Tyrosine-protein kinase, hepatocyte growth factor receptor
IPR020710 Tyrosine-protein kinase, insulin receptor
IPR020712 Tyrosine-protein kinase, insulin-related receptor
IPR020713 Tyrosine-protein kinase, insulin-like receptor, Drosphila
IPR020714 Tyrosine-protein kinase, insulin-like growth factor receptor
IPR020715 Tyrosine-protein kinase, receptor Ror2
IPR020716 Tyrosine-protein kinase, muscle/skeletal receptor
IPR020718 Tyrosine-protein kinase, PDGF/VEGF receptor, fly
IPR020720 Tyrosine-protein kinase, receptor Cad96
IPR020721 Tyrosine-protein kinase, vascular endothelial growth factor receptor 3 (VEGFR3)
IPR020722 Tyrosine-protein kinase, vascular endothelial growth factor receptor 1 (VEGFR1)
IPR020724 Tyrosine-protein kinase, receptor torso
IPR020725 Tyrosine-protein kinase, myoblast growth factor receptor Egl-15
IPR020727 Tyrosine-protein kinase, platelet-derived growth factor receptor beta
IPR020729 Tyrosine-protein kinase, macrophage colony-stimulating factor 1 receptor
IPR020730 Tyrosine-protein kinase, mast/stem cell growth factor receptor
IPR020732 Tyrosine-protein kinase, fibroblast growth factor receptor-related
IPR020733 Tyrosine-protein kinase, receptor kin-15/16
IPR020734 Tyrosine-protein kinase, FL cytokine receptor
IPR020735 Tyrosine-protein kinase, ALK receptor
IPR020736 Tyrosine-protein kinase, non-receptor Hopscotch
IPR020737 Serine/threonine-protein kinase, receptor LMTK
IPR020738 Tyrosine-protein kinase, receptor ROS/Sevenless
IPR020739 Tyrosine-protein kinase, MSP receptor
IPR020740 Tyrosine-protein kinase, receptor RYK
IPR020741 Tyrosine-protein kinase, receptor TYRO3
IPR020742 Tyrosine-protein kinase, discoidin domain-containing receptor
IPR020743 Tyrosine-protein kinase, non-receptor YES
IPR020744 Tyrosine-protein kinase, non-receptor Src
IPR020745 Tyrosine-protein kinase, non-receptor Fyn
IPR020746 Tyrosine-protein kinase, non-receptor Fgr
IPR020747 Tyrosine-protein kinase, non-receptor Lyn
IPR020748 Tyrosine-protein kinase, non-receptor Hck
IPR020749 Tyrosine-protein kinase, non-receptor Lck
IPR020750 Tyrosine-protein kinase, non-receptor Blk
IPR020753 Tyrosine-protein kinase, non-receptor Btk
IPR020755 Tyrosine-protein kinase, non-receptor Txk/Tec
IPR020757 Tyrosine-protein kinase, non-receptor SYK
IPR020760 Tyrosine-protein kinase, receptor erbB-2
IPR020762 Tyrosine-protein kinase, EGF receptor
IPR020763 Tyrosine-protein kinase, receptor ROR
IPR020764 Tyrosine-protein kinase, non-receptor Fes
IPR020766 Tyrosine-protein kinase, ephrin A10 receptor
IPR020767 Tyrosine-protein kinase, ephrin B6 receptor
IPR020768 Tyrosine-protein kinase, ephrin A receptor
IPR020769 Tyrosine-protein kinase, ephrin B receptor
IPR020770 Tyrosine-protein kinase, ephrin A1/A2 receptor
IPR020771 Tyrosine-protein kinase, non-receptor Shark
IPR020772 Tyrosine-protein kinase, receptor Daf-2
IPR020773 Tyrosine-protein kinase, non-receptor FADK
IPR020774 Tyrosine-protein kinase, receptor PTK7
IPR020775 Tyrosine-protein kinase, non-receptor Jak3
IPR020776 Tyrosine-protein kinase, non-receptor Jak1
IPR020777 Tyrosine-protein kinase, neurotrophic receptor
Contains IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
IPR003527 MAP kinase, conserved site
IPR008266 Tyrosine-protein kinase, active site
IPR008271 Serine/threonine-protein kinase, active site
IPR017441 Protein kinase, ATP binding site
IPR020659 Serine/threonine-protein kinase, predicted
GO Term annotationHelp
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Process GO:0006468 protein amino acid phosphorylation
Function GO:0004672 protein kinase activity
GO:0005524 ATP binding
InterPro annotation
BioMart Logo Entry Details in BioMart
AbstractHelp
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Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [1]:

  • Serine/threonine-protein kinases
  • Tyrosine-protein kinases
  • Dual specific protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)

Protein kinase function has been evolutionarily conserved from Escherichia coli to human [2]. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation [3]. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [4], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [5].

Eukaryotic protein kinases [6, 7, 8, 9, 1] are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. There are a number of conserved regions in the catalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is a glycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involved in ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residue which is important for the catalytic activity of the enzyme [10]. This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
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PDB - click here
1a06 , 1a9u , 1ad5 , 1agw , 1apm , 1aq1 , 1atp , 1b38 , 1b39 , 1b6c , 1bi7 , 1bi8 , 1bkx , 1bl6 , 1bl7 , 1blx , 1bmk , 1buh , 1bx6 , 1byg , 1cdk , 1cki , 1ckj , 1ckp , 1cm8 , 1cmk , 1csn , 1ctp , 1daw , 1day , 1di8 , 1di9 , 1dm2 , 1ds5 , 1e1v , 1e1x , 1e9h , 1eh4 , 1erk , 1f0q , 1f3m , 1f5q , 1fgi , 1fgk , 1fin , 1fmk , 1fmo , 1fot , 1fpu , 1fq1 , 1fvr , 1fvt , 1fvv , 1g3n , 1g5s , 1gag , 1gih , 1gii , 1gij , 1gjo , 1gng , 1gol , 1gy3 , 1gz8 , 1gzk , 1gzn , 1gzo , 1h00 , 1h01 , 1h07 , 1h08 , 1h0v , 1h0w , 1h1p , 1h1q , 1h1r , 1h1s , 1h1w , 1h24 , 1h25 , 1h26 , 1h27 , 1h28 , 1h4l , 1h8f , 1hck , 1hcl , 1how , 1i09 , 1i44 , 1ia8 , 1ian , 1ias , 1iep , 1ig1 , 1ir3 , 1irk , 1j1b , 1j1c , 1j3h , 1j91 , 1jam , 1jbp , 1jkk , 1jkl , 1jks , 1jkt , 1jlu , 1jnk , 1jow , 1jpa , 1jqh , 1jst , 1jsu , 1jsv , 1jvp , 1jwh , 1k2p , 1k3a , 1k9a , 1ke5 , 1ke6 , 1ke7 , 1ke8 , 1ke9 , 1koa , 1kob , 1ksw , 1kv1 , 1kv2 , 1kwp , 1l3r , 1lez , 1lp4 , 1lpu , 1lr4 , 1luf , 1m14 , 1m17 , 1m2p , 1m2q , 1m2r , 1m52 , 1m7n , 1m7q , 1mp8 , 1mq4 , 1mqb , 1mru , 1mrv , 1mry , 1muo , 1na7 , 1nvq , 1nvr , 1nvs , 1nxk , 1ny3 , 1o6k , 1o6l , 1o6y , 1o9u , 1ob3 , 1oec , 1ogu , 1oi9 , 1oiq , 1oir , 1oit , 1oiu , 1oiy , 1okv , 1okw , 1oky , 1okz , 1ol1 , 1ol2 , 1ol5 , 1ol6 , 1ol7 , 1om1 , 1omw , 1opj , 1opk , 1opl , 1ouk , 1ouy , 1ove , 1oz1 , 1p14 , 1p2a , 1p38 , 1p4f , 1p4o , 1p5e , 1pf8 , 1phk , 1pjk , 1pkd , 1pkg , 1pme , 1pmn , 1pmq , 1pmu , 1pmv , 1pw2 , 1pxi , 1pxj , 1pxk , 1pxl , 1pxm , 1pxn , 1pxo , 1pxp , 1py5 , 1pye , 1pyx , 1q24 , 1q3d , 1q3w , 1q41 , 1q4l , 1q5k , 1q61 , 1q62 , 1q8t , 1q8u , 1q8w , 1q8y , 1q8z , 1q97 , 1q99 , 1qcf , 1ql6 , 1qmz , 1qpc , 1qpd , 1qpe , 1qpj , 1r0e , 1r0p , 1r1w , 1r39 , 1r3c , 1r78 , 1rdq , 1re8 , 1rej , 1rek , 1rjb , 1rqq , 1rw8 , 1s9i , 1s9j , 1sm2 , 1smh , 1snu , 1snx , 1stc , 1sve , 1svg , 1svh , 1syk , 1szm , 1t45 , 1t46 , 1tki , 1tvo , 1u46 , 1u4d , 1u54 , 1u59 , 1u5q , 1u5r , 1ua2 , 1ukh , 1uki , 1ung , 1unh , 1unl , 1urc , 1urw , 1uu3 , 1uu7 , 1uu8 , 1uu9 , 1uv5 , 1uvr , 1uwh , 1uwj , 1v0b , 1v0o , 1v0p , 1v1k , 1veb , 1vjy , 1vr2 , 1vyw , 1vyz , 1vzo , 1w0x , 1w7h , 1w82 , 1w83 , 1w84 , 1w8c , 1w98 , 1wak , 1wbn , 1wbo , 1wbp , 1wbs , 1wbt , 1wbv , 1wbw , 1wcc , 1wfc , 1wvw , 1wvx , 1wvy , 1wzy , 1xba , 1xbb , 1xbc , 1xh4 , 1xh5 , 1xh6 , 1xh7 , 1xh8 , 1xh9 , 1xha , 1xjd , 1xkk , 1xo2 , 1xqz , 1xr1 , 1xws , 1y57 , 1y6a , 1y6b , 1y8y , 1y91 , 1ydr , 1yds , 1ydt , 1yhv , 1yhw , 1yi3 , 1yi4 , 1yi6 , 1ykr , 1ym7 , 1yqj , 1yrp , 1yvj , 1yw2 , 1ywn , 1ywr , 1ywv , 1yxs , 1yxt , 1yxu , 1yxv , 1yxx , 1z57 , 1z5m , 1zlt , 1zoe , 1zog , 1zoh , 1zrz , 1zyj , 1zys , 1zz2 , 1zzl , 2a0c , 2a4l , 2auh , 2ayp , 2b1p , 2b4s , 2b52 , 2b53 , 2b54 , 2b55 , 2b7a , 2b9f , 2b9h , 2b9i , 2b9j , 2baj , 2bak , 2bal , 2baq , 2bcj , 2bdf , 2bdj , 2bfx , 2bfy , 2bhe , 2bhh , 2bik , 2bil , 2biy , 2bkz , 2bmc , 2bpm , 2br1 , 2brb , 2brg , 2brh , 2brm , 2brn , 2bro , 2btr , 2bts , 2bva , 2bzh , 2bzi , 2bzj , 2bzk , 2c0i , 2c0o , 2c0t , 2c1a , 2c1b , 2c30 , 2c3i , 2c3j , 2c3k , 2c3l , 2c47 , 2c4g , 2c5n , 2c5o , 2c5v , 2c5x , 2c5y , 2c68 , 2c69 , 2c6d , 2c6e , 2c6i , 2c6k , 2c6l , 2c6m , 2c6o , 2c6t , 2cch , 2cci , 2cdz , 2cgu , 2cgv , 2cgw , 2cgx , 2chl , 2cjm , 2clx , 2cmw , 2cpk , 2csn , 2ds1 , 2duv , 2dwb , 2dyl , 2e14 , 2e9n , 2e9o , 2e9p , 2e9u , 2e9v , 2eb2 , 2eb3 , 2erk , 2erz , 2etm , 2euf , 2ewa , 2exc , 2exm , 2f2c , 2f49 , 2f4j , 2f57 , 2f7e , 2f7x , 2f7z , 2f9g , 2fa2 , 2fb8 , 2fgi , 2fo0 , 2fsl , 2fsm , 2fso , 2fst , 2fum , 2fvd , 2fys , 2g01 , 2g15 , 2g9x , 2gcd , 2gdo , 2gfc , 2gfs , 2ghg , 2ghl , 2ghm , 2gmx , 2gnf , 2gng , 2gnh , 2gni , 2gnj , 2gnl , 2gph , 2gs2 , 2gs6 , 2gsf , 2gtm , 2gtn , 2h34 , 2h8h , 2h96 , 2hck , 2hk5 , 2hog , 2hxl , 2hxq , 2hy0 , 2hy8 , 2hzn , 2i0e , 2i0h , 2i40 , 2i6l , 2ijm , 2itn , 2ito , 2itp , 2itq , 2itt , 2itu , 2itv , 2itw , 2itx , 2ity , 2itz , 2iw6 , 2iw8 , 2iw9 , 2iwi , 2izr , 2izs , 2izt , 2izu , 2j0i , 2j2i , 2j4z , 2j50 , 2j51 , 2j5f , 2j6m , 2j7t , 2j9m , 2jav , 2jbp , 2jd5 , 2jdo , 2jdr , 2jds , 2jed , 2jfl , 2jfm , 2jgz , 2jit , 2jiu , 2jiv , 2no3 , 2npq , 2o0u , 2o2u , 2o3p , 2o5k , 2o63 , 2o64 , 2o65 , 2obj , 2of2 , 2of4 , 2ofu , 2ofv , 2og8 , 2oh0 , 2oi4 , 2oj9 , 2ojf , 2ojg , 2oji , 2ojj , 2ok1 , 2okr , 2onl , 2ow3 , 2oxd , 2oxx , 2oxy , 2oza , 2p2i , 2p33 , 2p55 , 2pe0 , 2pe1 , 2pe2 , 2phk , 2pk9 , 2pkj , 2pl0 , 2pmi , 2psq , 2ptj , 2ptk , 2pto , 2pv5 , 2pv8 , 2pvh , 2pvj , 2pvk , 2pvl , 2pvm , 2pvn , 2pvr , 2q0n , 2qc6 , 2qcs , 2qd9 , 2qhm , 2qhn , 2qkr , 2qlu , 2qoh , 2qvs , 2r0u , 2r3f , 2r3g , 2r3h , 2r3i , 2r3j , 2r3k , 2r3l , 2r3m , 2r3n , 2r3o , 2r3p , 2r3q , 2r3r , 2r7b , 2r7i , 2r9s , 2rf9 , 2rg5 , 2rg6 , 2src , 2uue , 2uv2 , 2uw9 , 2uzb , 2uzd , 2uze , 2uzl , 2uzn , 2uzo , 2v0d , 2v22 , 2vgp , 2vo7 , 2ywp , 2z7l , 2z8c , 2zaz , 2zb0 , 2zb1 , 2zdt , 2zdu , 2zm1 , 2zm3 , 2zm4 , 3b2w , 3beg , 3bgp , 3bgq , 3bgz , 3bht , 3bhu , 3bhv , 3blh , 3blq , 3blr , 3bqc , 3bu3 , 3bu5 , 3bu6 , 3bv2 , 3bv3 , 3bw5 , 3bx5 , 3bym , 3bys , 3byu , 3bz3 , 3c13 , 3c1x , 3c4c , 3c4d , 3c4e , 3c5u , 3c9w , 3ce3 , 3cg2 , 3cgf , 3cgo , 3ckw , 3ckx , 3coi , 3com , 3cth , 3ctj , 3d0e , 3d7u , 3d7z , 3d83 , 3dcv , 3ds6 , 3dt1 , 3e87 , 3e88 , 3e8d , 3e92 , 3e93 , 3erk , 3lck , 4erk
SCOP: d.144.1.7
Database linksHelp
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Enzyme: EC:2.7
PROSITE doc: PDOC00100
InteractionsHelp
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This domain has been experimentally proven to be involved in Protein:Protein interactions.
Representative data is shown with the following example proteins:

Taxonomic coverageHelp
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Overlapping InterPro entriesHelp
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IPR000719 Numbers of overlapping proteins Average numbers of overlapping amino acids

Example proteinsHelp
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A2CG49 Kalirin

O00141 Serine/threonine-protein kinase Sgk1

O01761 Muscle M-line assembly protein unc-89

P04412 Epidermal growth factor receptor

P06244 cAMP-dependent protein kinase type 1

More proteins


Example Proteins Key


InterPro entry accession number/name and structure databases Colour code
IPR006212 Furin-like repeat
IPR013783 Immunoglobulin-like fold
IPR001251 Cellular retinaldehyde-binding/triple function, C-terminal
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
IPR006211 Furin-like cysteine-rich domain
IPR013098 Immunoglobulin I-set
IPR009030 Growth factor, receptor
IPR007850 RCSD
IPR017892 Protein kinase, C-terminal
IPR011009 Protein kinase-like domain
IPR008957 Fibronectin, type III-like fold
IPR018159 Spectrin/alpha-actinin
IPR020635 Tyrosine-protein kinase, subgroup, catalytic domain
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR011511 Variant SH3
IPR003961 Fibronectin, type III
IPR002017 Spectrin repeat
IPR011993 Pleckstrin homology-type
IPR007110 Immunoglobulin-like
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR001245 Tyrosine-protein kinase, catalytic domain
IPR001849 Pleckstrin homology
IPR000219 Dbl homology (DH) domain
IPR001452 Src homology-3 domain
IPR008266 Tyrosine-protein kinase, active site
IPR000494 EGF receptor, L domain
IPR015780 Tyrosine-protein kinase, epidermal growth factor receptor-related
IPR020685 Tyrosine-protein kinase
IPR008271 Serine/threonine-protein kinase, active site
IPR000961 AGC-kinase, C-terminal
IPR009134 Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal
ModBase
SWISS-MODEL
PDB Chain
CATH Domain
SCOP Domain

PublicationsHelp
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1. Hanks SK, Quinn AM, Hunter T.
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
Science 241 42-52 1988 [PubMed: 3291115]
http://www.sciencemag.org/cgi/content/abstract/241/4861/42
2. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S.
The protein kinase complement of the human genome.
Science 298 1912-34 2002 [PubMed: 12471243]
http://dx.doi.org/10.1126/science.1075762
3. Manning G, Plowman GD, Hunter T, Sudarsanam S.
Evolution of protein kinase signaling from yeast to man.
Trends Biochem. Sci. 27 514-20 2002 [PubMed: 12368087]
http://dx.doi.org/10.1016/S0968-0004(02)02179-5
4. Stout TJ, Foster PG, Matthews DJ.
High-throughput structural biology in drug discovery: protein kinases.
Curr. Pharm. Des. 10 1069-82 2004 [PubMed: 15078142]
http://dx.doi.org/10.2174/1381612043452695
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