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InterPro: IPR000669 Mannitol dehydrogenase, core

Protein matches Help

UniProtKB

Matches:

1330 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR000669 Mannitol_DH_core

Type

Domain

Signatures Help

Database	ID	Name	Proteins
PRINTS	PR00084	MTLDHDRGNASE	1325
PROSITE pattern	PS00974	MANNITOL_DHGENASE	992
Signatures in BioMart

InterPro Relationships Help

Parent

IPR016040 NAD(P)-binding domain

Contains

IPR013131 Mannitol dehydrogenase, N-terminal

GO Term annotation Help

Process

GO:0008152 metabolic process
GO:0055114 oxidation reduction

Function

GO:0003824 catalytic activity

InterPro annotation

Entry Details in BioMart

Abstract

Mannitol-1-phosphate 5-dehydrogenase catalyses the NAD-dependent reduction of mannitol-1-phosphate to fructose-6-phosphate [1] as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The PTS facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glycolytic intermediates [2]. Mannitol 2-dehydrogenase catalyses the NAD-dependent reduction of mannitol to fructose [3]. Several dehydrogenases have been shown [3] to be evolutionary related, including mannitol-1-phosphate 5-dehydrogenase (EC:1.1.1.17) (gene mtlD), mannitol 2-dehydrogenase (EC:1.1.1.67) (gene mtlK); mannonate oxidoreductase (EC:1.1.1.57) (fructuronate reductase) (gene uxuB); Escherichia coli hypothetical proteins ydfI and yeiQ; and yeast hypothetical protein YEL070w.

Structural links Help

PDB - click here

SCOP: c.2.1.6

CATH: 3.40.50.720

Database links Help

PDBe-motif: PS00974

Enzyme: EC:1.1.1.17

PROSITE doc: PDOC00751

Blocks: IPB000669

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR000669

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A1C6B4 Mannitol-1-phosphate 5-dehydrogenase

P39941 Mannitol dehydrogenase DSF1

Q83PQ0 Mannitol-1-phosphate 5-dehydrogenase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR008927	6-phosphogluconate dehydrogenase, C-terminal-like
IPR013118	Mannitol dehydrogenase, C-terminal
IPR016040	NAD(P)-binding domain
IPR013131	Mannitol dehydrogenase, N-terminal
IPR013328	Dehydrogenase, multihelical
IPR000669	Mannitol dehydrogenase, core
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Fischer R, von Strandmann RP, Hengstenberg W. Mannitol-specific phosphoenolpyruvate-dependent phosphotransferase system of Enterococcus faecalis: molecular cloning and nucleotide sequences of the enzyme IIIMtl gene and the mannitol-1-phosphate dehydrogenase gene, expression in Escherichia coli, and comparison of the gene products with similar enzymes. J. Bacteriol. 173 3709-15 1991 [PubMed: 1904856] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=1904856
2.	Honeyman AL, Curtiss R 3rd. Isolation, characterization, and nucleotide sequence of the Streptococcus mutans mannitol-phosphate dehydrogenase gene and the mannitol-specific factor III gene of the phosphoenolpyruvate phosphotransferase system. Infect. Immun. 60 3369-75 1992 [PubMed: 1322373] http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=1322373&action=stream&blobtype=pdf
3.	Schneider KH, Giffhorn F, Kaplan S. Cloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodobacter sphaeroides. J. Gen. Microbiol. 139 2475-84 1993 [PubMed: 8254318]

Additional Reading Open in usermanual
	Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK. Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase binary and ternary complexes. Specificity and catalytic mechanism. J. Biol. Chem. 277 2002 43433-42 [PubMed: 12196534] http://dx.doi.org/10.1074/jbc.M206914200

InterPro 23.1