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InterPro: IPR000506 Acetohydroxy acid isomeroreductase C-terminal

Protein matches Help

UniProtKB

Matches:

1688 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR000506 AcH_isomrdctse_C

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01450	IlvC	1688
Signatures in BioMart

InterPro Relationships Help

Found in

IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR013023 Acetohydroxy acid isomeroreductase
IPR014359 Ketol-acid reductoisomerase, gammaproteobacteria
IPR016206 Ketol-acid reductoisomerase, plant
IPR016207 Ketol-acid reductoisomerase, fungi

GO Term annotation Help

Process

GO:0009082 branched chain family amino acid biosynthetic process
GO:0055114 oxidation reduction

Function

GO:0004455 ketol-acid reductoisomerase activity

InterPro annotation

Entry Details in BioMart

Abstract

Acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine [1]. The enzyme forms a tetramer of similar but non-identical chains, and requires magnesium as a cofactor.

Structural links Help

PDB - click here

SCOP: a.100.1.2

CATH: 1.10.1040.10

Database links Help

Enzyme: EC:1.1.1.86

PANDIT: PF01450

Blocks: IPB000506

CluSTr: ALLvsALL:31618:47.9

Pfam Clan: CL0106.9

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR000506

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P05793 Ketol-acid reductoisomerase

P06168 Ketol-acid reductoisomerase, mitochondrial

P29107 Ketol-acid reductoisomerase

Q05758 Ketol-acid reductoisomerase, chloroplastic

Q65XK0 Ketol-acid reductoisomerase, chloroplastic

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR008927	6-phosphogluconate dehydrogenase, C-terminal-like
IPR016040	NAD(P)-binding domain
IPR014359	Ketol-acid reductoisomerase, gammaproteobacteria
IPR016207	Ketol-acid reductoisomerase, fungi
IPR016206	Ketol-acid reductoisomerase, plant
IPR013116	Acetohydroxy acid isomeroreductase, catalytic
IPR013328	Dehydrogenase, multihelical
IPR000506	Acetohydroxy acid isomeroreductase C-terminal
IPR013023	Acetohydroxy acid isomeroreductase
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Biou V, Dumas R, Cohen-Addad C, Douce R, Job D, Pebay-Peyroula E. The crystal structure of plant acetohydroxy acid isomeroreductase complexed with NADPH, two magnesium ions and a herbicidal transition state analog determined at 1.65 A resolution. EMBO J. 16 3405-15 1997 [PubMed: 9218783] http://dx.doi.org/10.1093/emboj/16.12.3405

Additional Reading Open in usermanual
	Thomazeau K, Dumas R, Halgand F, Forest E, Douce R, Biou V. Structure of spinach acetohydroxyacid isomeroreductase complexed with its reaction product dihydroxymethylvalerate, manganese and (phospho)-ADP-ribose. Acta Crystallogr. D Biol. Crystallogr. 56 2000 389-97 [PubMed: 10739911] http://dx.doi.org/10.1107/S0907444900001694
	Ahn HJ, Eom SJ, Yoon HJ, Lee BI, Cho H, Suh SW. Crystal structure of class I acetohydroxy acid isomeroreductase from Pseudomonas aeruginosa. J. Mol. Biol. 328 2003 505-15 [PubMed: 12691757] http://dx.doi.org/10.1016/S0022-2836(03)00264-X

InterPro 23.1