EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR000490 Glycoside hydrolase, family 17

Protein matches Help

UniProtKB

Matches:

1359 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR000490 Glyco_hydro_17

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF00332	Glyco_hydro_17	1335
PROSITE pattern	PS00587	GLYCOSYL_HYDROL_F17	756
Signatures in BioMart

InterPro Relationships Help

Contains

IPR013781 Glycoside hydrolase, subgroup, catalytic core

GO Term annotation Help

Process

GO:0005975 carbohydrate metabolic process

Function

GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds

InterPro annotation

Entry Details in BioMart

Abstract

O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [1, 2, 3]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [4]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in clans.

Glycoside hydrolase family 17 GH17 comprises enzymes with several known activities; endo-1,3-beta-glucosidase (EC:3.2.1.39); lichenase (EC:3.2.1.73); exo-1,3-glucanase (EC:3.2.1.58). Currently these enzymes have only been found in plants and in fungi.

Structural links Help

PDB - click here

SCOP: c.1.8.3

CATH: 3.20.20.80

Database links Help

PDBe-motif: PS00587

Enzyme: EC:3.2.1.39

CAZy: GH17

PROSITE doc: PDOC00507

PANDIT: PF00332

Blocks: IPB000490

Pfam Clan: CL0058.12

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR000490

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O13990 Glucan 1,3-beta-glucosidase

O65399 Glucan endo-1,3-beta-glucosidase 1

P15703 Glucan 1,3-beta-glucosidase

P15737 Glucan endo-1,3-beta-glucosidase GII

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000490	Glycoside hydrolase, family 17
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR012946	X8
IPR017853	Glycoside hydrolase, catalytic core
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proc. Natl. Acad. Sci. U.S.A. 92 7090-4 1995 [PubMed: 7624375] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=7624375&action=stream&blobtype=pdf
2.	Davies G, Henrissat B. Structures and mechanisms of glycosyl hydrolases. Structure 3 853-9 1995 [PubMed: 8535779] http://dx.doi.org/10.1016/S0969-2126(01)00220-9
3.	Bairoch A. Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT. 1999
4.	Henrissat B, Coutinho PM. Carbohydrate-Active Enzymes server. 1999

Additional Reading Open in usermanual
	Muller JJ, Thomsen KK, Heinemann U. Crystal structure of barley 1,3-1,4-beta-glucanase at 2.0-A resolution and comparison with Bacillus 1,3-1,4-beta-glucanase. J. Biol. Chem. 273 1998 3438-46 [PubMed: 9452466] http://dx.doi.org/10.1074/jbc.273.6.3438
	Receveur-Brechot V, Czjzek M, Barre A, Roussel A, Peumans WJ, Van Damme EJ, Rouge P. Crystal structure at 1.45-A resolution of the major allergen endo-beta-1,3-glucanase of banana as a molecular basis for the latex-fruit syndrome. Proteins 63 2006 235-42 [PubMed: 16421930] http://dx.doi.org/10.1002/prot.20876
	Varghese JN, Garrett TP, Colman PM, Chen L, Hoj PB, Fincher GB. Three-dimensional structures of two plant beta-glucan endohydrolases with distinct substrate specificities. Proc. Natl. Acad. Sci. U.S.A. 91 1994 2785-9 [PubMed: 8146192] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=8146192
	Ori N, Sessa G, Lotan T, Himmelhoch S, Fluhr R. A major stylar matrix polypeptide (sp41) is a member of the pathogenesis-related proteins superclass. EMBO J. 9 1990 3429-36 [PubMed: 2120041] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=2120041
	Henrissat B. A classification of glycosyl hydrolases based on amino acid sequence similarities. Biochem. J. 280 ( Pt 2) 1991 309-16 [PubMed: 1747104] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=1747104

InterPro 23.1