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InterPro: IPR000462 CDP-alcohol phosphatidyltransferase

Protein matches Help

UniProtKB

Matches:

4819 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR000462 CDP-OH_P_trans

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01066	CDP-OH_P_transf	4787
PROSITE pattern	PS00379	CDP_ALCOHOL_P_TRANSF	4251
Signatures in BioMart

InterPro Relationships Help

Children

IPR004533 CDP-diacylglycerol--serine O-phosphatidyltransferase
IPR004570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
IPR014387 CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote
IPR014472 Choline/ethanolaminephosphotransferase

GO Term annotation Help

Process

GO:0008654 phospholipid biosynthetic process

Function

GO:0016780 phosphotransferase activity, for other substituted phosphate groups

Component

GO:0016020 membrane

InterPro annotation

Entry Details in BioMart

Abstract

A number of phosphatidyltransferases, which are all involved in phospholipid biosynthesis and that share the property of catalyzing the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond share a conserved sequence region [1, 2]. These enzymes are proteins of from 200 to 400 amino acid residues. The conserved region contains three aspartic acid residues and is located in the N-terminal section of the sequences.

Database links Help

PDBe-motif: PS00379

Enzyme: EC:2.7.8

PROSITE doc: PDOC00321

PANDIT: PF01066

Blocks: IPB000462

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR000462

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O01916 Probable cardiolipin synthetase 1

O14735 CDP-diacylglycerol--inositol 3-phosphatidyltransferase

P06197 CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Q80TA1 Ethanolaminephosphotransferase 1

Q8MZC4 Probable cardiolipin synthetase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR014472	Choline/ethanolaminephosphotransferase
IPR000462	CDP-alcohol phosphatidyltransferase
IPR014387	CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote
	ModBase

Publications Open in usermanual
1.	Nikawa J, Kodaki T, Yamashita S. Primary structure and disruption of the phosphatidylinositol synthase gene of Saccharomyces cerevisiae. J. Biol. Chem. 262 4876-81 1987 [PubMed: 3031032] http://intl.jbc.org/cgi/content/abstract/262/10/4876
2.	Hjelmstad RH, Bell RM. sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Nucleotide sequence of the EPT1 gene and comparison of the CPT1 and EPT1 gene products. J. Biol. Chem. 266 5094-103 1991 [PubMed: 1848238] http://intl.jbc.org/cgi/reprint/266/8/5094.pdf

Additional Reading Open in usermanual
	Morein S, Trouard TP, Hauksson JB, Rilfors L, Arvidson G, Lindblom G. Two-dimensional 1H-NMR of transmembrane peptides from Escherichia coli phosphatidylglycerophosphate synthase in micelles. Eur. J. Biochem. 241 1996 489-97 [PubMed: 8917447] http://dx.doi.org/10.1111/j.1432-1033.1996.00489.x

InterPro 23.1