EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR000396 Cyclic-AMP phosphodiesterase, class-II

Protein matches Help

UniProtKB

Matches:

170 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR000396 Pdiesterase2

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02112	PDEase_II	118
PIRSF	PIRSF000962	Cyc_nuc_PDEase	75
PRINTS	PR00388	PDIESTERASE2	169
PROSITE pattern	PS00607	PDEASE_II	58
Signatures in BioMart

GO Term annotation Help

Process

GO:0006198 cAMP catabolic process

Function

GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity

InterPro annotation

Entry Details in BioMart

Abstract

Cyclic-AMP phosphodiesterase (EC:3.1.4.17) (PDE) catalyses the hydrolysis of cAMP to the corresponding nucleoside 5' monophosphate. On the basis of sequence similarity, most PDEs can be grouped together [1], but 2 enzymes lie apart from the main family and represent a second distinct class [2]: this includes PDEs from Dictyostelium and yeast. There is, in the central part of these enzymes, a highly conserved region which contains three histidines.

Database links Help

PDBe-motif: PS00607

Enzyme: EC:3.1.4

PROSITE doc: PDOC00530

PANDIT: PF02112

Blocks: IPB000396

Taxonomic coverage Help

Example proteins Help

P12019 cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase A

P22434 3',5'-cyclic-nucleotide phosphodiesterase 1

P32782 3',5'-cyclic-nucleotide phosphodiesterase

Q56686 3',5'-cyclic-nucleotide phosphodiesterase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR001279	Beta-lactamase-like
IPR000396	Cyclic-AMP phosphodiesterase, class-II
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Beavo JA, Reifsnyder DH. Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol. Sci. 11 150-5 1990 [PubMed: 2159198] http://dx.doi.org/10.1016/0165-6147(90)90066-H
2.	Nikawa J, Sass P, Wigler M. Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae. Mol. Cell. Biol. 7 3629-36 1987 [PubMed: 2824992] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=2824992&action=stream&blobtype=pdf

Additional Reading Open in usermanual
	Dunlap PV, Callahan SM. Characterization of a periplasmic 3':5'-cyclic nucleotide phosphodiesterase gene, cpdP, from the marine symbiotic bacterium Vibrio fischeri. J. Bacteriol. 175 1993 4615-24 [PubMed: 8393003] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=8393003&action=stream&blobtype=pdf

InterPro 23.1