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InterPro: IPR000024 Frizzled cysteine-rich domain

Protein matches Help

UniProtKB

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567 proteins

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Accession List
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Accession

IPR000024 Frizzled_Cys-rich

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:1.10.2000.10	Frizzled_Cys-rich	518
SuperFamily	SSF63501	Frizzled_Cys-rich	567
Signatures in BioMart

InterPro Relationships Help

Parent

IPR020067 Frizzled-like domain

Children

IPR020068 Frizzled domain, subgroup

Found in

IPR015526 Frizzled related
IPR017052 Atrial natriuteric peptide-converting enzyme
IPR017343 Uncharacterised conserved protein UCP037987

InterPro annotation

Entry Details in BioMart

Abstract

The Frizzled CRD (cysteine rich domain) is conserved in diverse proteins including several receptor tyrosine kinases [1, 2, 3]. In Drosophila melanogaster, members of the Frizzled family of tissue-polarity genes encode proteins that appear to function as cell-surface receptors for Wnts. The Frizzled genes belong to the seven transmembrane class of receptors (7TMR) and have in their extracellular region a cysteine-rich domain that has been implicated as the Wnt binding domain. Sequence similarity between the cysteine-rich domain of Frizzled and several receptor tyrosine kinases, which have roles in development, include the muscle-specific receptor tyrosine kinase (MuSK), the neuronal specific kinase (NSK2), and ROR1 and ROR2. The structure of this domain is known and is composed mainly of alpha helices. This domain contains ten conserved cysteines that form five disulphide bridges.

Structural links Help

PDB - click here

SCOP: a.141.1.1

CATH: 1.10.2000.10

Database links Help

PROSITE doc: PDOC50038

PANDIT: PF01392

Blocks: IPB000024

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR000024

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O00144 Frizzled-9

O19116 Secreted frizzled-related protein 1

O77438 Frizzled-3

P39061 Collagen alpha-1(XVIII) chain

Q24760 Frizzled

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR010515	Collagenase NC10/endostatin
IPR001791	Laminin G
IPR000539	Frizzled protein
IPR001134	Netrin domain
IPR020068	Frizzled domain, subgroup
IPR017981	GPCR, family 2-like
IPR016187	C-type lectin fold
IPR020067	Frizzled-like domain
IPR016186	C-type lectin-like
IPR015526	Frizzled related
IPR008993	TIMP-like, OB-fold
IPR000024	Frizzled cysteine-rich domain
IPR018933	Netrin module, non-TIMP type
IPR008160	Collagen triple helix repeat
IPR008985	Concanavalin A-like lectin/glucanase
IPR010363	Protein of unknown function DUF959, collagen XVIII, N-terminal
IPR003129	Laminin G, thrombospondin-type, N-terminal
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Xu YK, Nusse R. The Frizzled CRD domain is conserved in diverse proteins including several receptor tyrosine kinases. Curr. Biol. 8 R405-6 1998 [PubMed: 9637908] http://dx.doi.org/10.1016/S0960-9822(98)70262-3
2.	Saldanha J, Singh J, Mahadevan D. Identification of a Frizzled-like cysteine rich domain in the extracellular region of developmental receptor tyrosine kinases. Protein Sci. 7 1632-5 1998 [PubMed: 9684897] http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=9684897&action=stream&blobtype=pdf
3.	Rehn M, Pihlajaniemi T, Hofmann K, Bucher P. The frizzled motif: in how many different protein families does it occur? Trends Biochem. Sci. 23 415-7 1998 [PubMed: 9852758] http://dx.doi.org/10.1016/S0968-0004(98)01290-0

Additional Reading Open in usermanual
	Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 412 2001 86-90 [PubMed: 11452312] http://dx.doi.org/10.1038/35083601

InterPro 23.1