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InterPro: IPR004114 THUMP

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UniProtKB

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2260 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
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Accession

IPR004114 THUMP

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02926	THUMP	1969
PROSITE profile	PS51165	THUMP	2236
Signatures in BioMart

InterPro Relationships Help

Found in

IPR003720 Thiamine biosynthesis protein
IPR005912 Conserved hypothetical protein CHP01213
IPR017244 S-adenosyl-L-dependent RNA methyltransferase, bacteria,

InterPro annotation

Entry Details in BioMart

Abstract

The THUMP domain is shared by 4-thiouridine, pseudouridine synthases and RNA methylases[1] and is probably an RNA-binding domain that adopts an alpha/beta fold similar to that found in the C-terminal domain of translation initiation factor 3 and ribosomal protein S8. The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets [1].

This domain is found in the thiamine biosynthesis proteins (ThiI) (see IPR003720).

Structural links Help

PDB - click here

SCOP: d.308.1.1 , d.308.1.3

Database links Help

PROSITE doc: PDOC51165

PANDIT: PF02926

Blocks: IPB004114

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004114

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P53072 tRNA acetyltransferase TAN1

P97770 THUMP domain-containing protein 3

Q55156 Putative RNA methyltransferase slr0064

Q9NXG2 THUMP domain-containing protein 1

Q9VZD8 THUMP domain-containing protein 1 homolog

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002296	N6 adenine-specific DNA methyltransferase, N12 class
IPR004114	THUMP
IPR002052	DNA methylase, N-6 adenine-specific, conserved site
IPR000241	Putative RNA methylase
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Open in usermanual
1.	Aravind L, Koonin EV. THUMP--a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases. Trends Biochem. Sci. 26 215-7 2001 [PubMed: 11295541] http://dx.doi.org/10.1016/S0968-0004(01)01826-6

Additional Reading Open in usermanual
	Sugahara M, Murai S, Sugahara M, Kunishima N. Purification, crystallization and preliminary crystallographic analysis of the putative thiamine-biosynthesis protein PH1313 from Pyrococcus horikoshii OT3. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 2007 56-8 [PubMed: 17183176]
	Waterman DG, Ortiz-Lombardia M, Fogg MJ, Koonin EV, Antson AA. Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domain. J. Mol. Biol. 356 2006 97-110 [PubMed: 16343540] http://dx.doi.org/10.1016/j.jmb.2005.11.013

InterPro 23.1