The splicing factor Prp18 is required for the second step of pre-mRNA
splicing. PRP18 appears to
be primarily associated with the U5 snRNP.
The structure of a large fragment of the Saccharomyces cerevisiae
Prp18 is known [1]. This fragment is fully active in yeast splicing in vitro and
includes the sequences of Prp18 that have been evolutionarily conserved.
The core structure consists of five alpha-helices that adopt a novel fold. The
most highly conserved region of Prp18, a nearly invariant stretch of 19 aa,
forms part of a loop between two alpha-helices and may interact with the
U5 small nuclear ribonucleoprotein particles [1].
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