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InterPro: IPR003837 Glu-tRNAGln amidotransferase, C subunit

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1362 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003837 Glu-tRNAGlntrans

Secondary

IPR004415

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02686	Glu-tRNAGln	1274
TIGRFAMs	TIGR00135	gatC	1341
Signatures in BioMart

GO Term annotation Help

Process

GO:0006450 regulation of translational fidelity

InterPro annotation

Entry Details in BioMart

Abstract

Glu-tRNAGln amidotransferase is a heterotrimeric enzyme that is required for correct decoding of glutamine codons during translation. The Glu-tRNA Gln amidotransferase enzyme is an important translational fidelity mechanism replacing incorrectly charged Glu-tRNAGln with the correct Gln-tRANGln via transmidation of the misacylated Glu-tRNAGln [1]. This activity supplements the lack of glutaminyl-tRNA synthetase activity in Gram-positive eubacteria, cyanobacteria, archaea, and organelles [1].

Structural links Help

PDB - click here

SCOP: a.137.12.1

Database links Help

Enzyme: EC:6.3.5

PANDIT: PF02686

Blocks: IPB003837

Taxonomic coverage Help

Example proteins Help

O43716 GatC-like protein

O67904 Glutamyl-tRNA(Gln) amidotransferase subunit C

Q2KIF1 GatC-like protein

Q55450 Glutamyl-tRNA(Gln) amidotransferase subunit C

Q8CBY0 GatC-like protein

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003837	Glu-tRNAGln amidotransferase, C subunit
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Curnow AW, Hong K, Yuan R, Kim S, Martins O, Winkler W, Henkin TM, Soll D. Glu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation. Proc. Natl. Acad. Sci. U.S.A. 94 11819-26 1997 [PubMed: 9342321] http://dx.doi.org/10.1073/pnas.94.22.11819

Additional Reading Open in usermanual
	Nakamura A, Yao M, Chimnaronk S, Sakai N, Tanaka I. Ammonia channel couples glutaminase with transamidase reactions in GatCAB. Science 312 2006 1954-8 [PubMed: 16809541] http://dx.doi.org/10.1126/science.1127156

InterPro 23.1