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InterPro: IPR003732 D-tyrosyl-tRNA(Tyr) deacylase

Protein matches Help

UniProtKB

Matches:

1509 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003732 DTyrtRNA_deacyls

Type

Family

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:3.50.80.10	DTyrtRNA_deacyls	1415
HAMAP	MF_00518	DTyrtRNA_deacyls	1091
Pfam	PF02580	Tyr_Deacylase	1506
PANTHER	PTHR10472	DTyrtRNA_deacyls	1489
SuperFamily	SSF69500	DTyrtRNA_deacyls	1498
TIGRFAMs	TIGR00256	DTyrtRNA_deacyls	1422
Signatures in BioMart

GO Term annotation Help

Process

GO:0019478 D-amino acid catabolic process

Function

GO:0016788 hydrolase activity, acting on ester bonds

Component

GO:0005737 cytoplasm

InterPro annotation

Entry Details in BioMart

Abstract

This homodimeric enzyme appears able to cleave any D-amino acid (and glycine, which does not have distinct D/L forms) from charged tRNA. The name reflects characterization with respect to D-Tyr on tRNA(Tyr) as established in the literature, but substrate specificity seems much broader.

Structural links Help

PDB - click here

SCOP: c.110.1.1

CATH: 3.50.80.10

Database links Help

Enzyme: EC:3.1

PANDIT: PF02580

Blocks: IPB003732

Taxonomic coverage Help

Example proteins Help

O66742 D-tyrosyl-tRNA(Tyr) deacylase

Q07648 D-tyrosyl-tRNA(Tyr) deacylase

Q2T9V8 D-tyrosyl-tRNA(Tyr) deacylase 1

Q8BHA3 Probable D-tyrosyl-tRNA(Tyr) deacylase 2

Q8TEA8 D-tyrosyl-tRNA(Tyr) deacylase 1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003732	D-tyrosyl-tRNA(Tyr) deacylase
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain

Publications Help

Additional Reading Open in usermanual
	Kemp M, Bae B, Yu JP, Ghosh M, Leffak M, Nair SK. Structure and function of the c-myc DNA-unwinding element-binding protein DUE-B. J. Biol. Chem. 282 2007 10441-8 [PubMed: 17264083] http://dx.doi.org/10.1074/jbc.M609632200
	Lim K, Tempczyk A, Bonander N, Toedt J, Howard A, Eisenstein E, Herzberg O. A catalytic mechanism for D-Tyr-tRNATyr deacylase based on the crystal structure of Hemophilus influenzae HI0670. J. Biol. Chem. 278 2003 13496-502 [PubMed: 12571243] http://dx.doi.org/10.1074/jbc.M213150200
	Ferri-Fioni ML, Schmitt E, Soutourina J, Plateau P, Mechulam Y, Blanquet S. Structure of crystalline D-Tyr-tRNA(Tyr) deacylase. A representative of a new class of tRNA-dependent hydrolases. J. Biol. Chem. 276 2001 47285-90 [PubMed: 11568181] http://dx.doi.org/10.1074/jbc.M106550200

InterPro 23.1