EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR003100 Argonaute/Dicer protein, PAZ

Protein matches Help

UniProtKB

Matches:

892 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003100 PAZ

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02170	PAZ	835
PROSITE profile	PS50821	PAZ	829
Signatures in BioMart

InterPro annotation

Entry Details in BioMart

Abstract

This domain is named after the proteins Piwi Argonaut and Zwille. It is also found in the CAF protein from Arabidopsis thaliana. The function of the domain is unknown but has been found in the middle region of a number of members of the Argonaute protein family, which also contain the Piwi domain (IPR003165) in their C-terminal region [1]. Several members of this family have been implicated in the development and maintenance of stem cells through the RNA-mediated gene-quelling mechanisms associated with the protein DICER.

Structural links Help

PDB - click here

SCOP: b.34.14.1

CATH: 2.170.260.10

Database links Help

PROSITE doc: PDOC50821

PANDIT: PF02170

Blocks: IPB003100

Taxonomic coverage Help

Example proteins Help

O04379 Protein argonaute

P34529 Endoribonuclease dcr-1

Q8R418 Endoribonuclease Dicer

Q9UL18 Protein argonaute-1

Q9VUQ5 Protein argonaute-2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR006935	Restriction endonuclease, type I, R subunit/Type III, Res subunit
IPR005034	Dicer double-stranded RNA-binding fold
IPR003100	Argonaute/Dicer protein, PAZ
IPR014811	Domain of unknown function DUF1785
IPR001159	Double-stranded RNA binding
IPR014021	Helicase, superfamily 1/2, ATP-binding domain
IPR012337	Polynucleotidyl transferase, ribonuclease H fold
IPR000999	Ribonuclease III
IPR001650	DNA/RNA helicase, C-terminal
IPR011545	DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR003165	Stem cell self-renewal protein Piwi
IPR014001	DEAD-like helicase, N-terminal
IPR014720	Double-stranded RNA-binding-like
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Sasaki T, Shiohama A, Minoshima S, Shimizu N. Identification of eight members of the Argonaute family in the human genome small star, filled. Genomics 82 323-30 2003 [PubMed: 12906857] http://dx.doi.org/10.1016/S0888-7543(03)00129-0

Additional Reading Open in usermanual
	Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L. The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat. Struct. Biol. 10 2003 1026-32 [PubMed: 14625589] http://dx.doi.org/10.1038/nsb1016
	Cerutti L, Mian N, Bateman A. Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain. Trends Biochem. Sci. 25 2000 481-2 [PubMed: 11050429] http://dx.doi.org/10.1016/S0968-0004(00)01641-8
	Lingel A, Simon B, Izaurralde E, Sattler M. Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature 426 2003 465-9 [PubMed: 14615801] http://dx.doi.org/10.1038/nature02123
	Yan KS, Yan S, Farooq A, Han A, Zeng L, Zhou MM. Structure and conserved RNA binding of the PAZ domain. Nature 426 2003 468-74 [PubMed: 14615802] http://dx.doi.org/10.1038/nature02129
	Hammond SM, Caudy AA, Hannon GJ. Post-transcriptional gene silencing by double-stranded RNA. Nat. Rev. Genet. 2 2001 110-9 [PubMed: 11253050] http://dx.doi.org/10.1038/35052556
	Lingel A, Simon B, Izaurralde E, Sattler M. Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat. Struct. Mol. Biol. 11 2004 576-7 [PubMed: 15156196] http://dx.doi.org/10.1038/nsmb777
	Ma JB, Ye K, Patel DJ. Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature 429 2004 318-22 [PubMed: 15152257] http://dx.doi.org/10.1038/nature02519
	Bernstein E, Caudy AA, Hammond SM, Hannon GJ. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409 2001 363-6 [PubMed: 11201747] http://dx.doi.org/10.1038/35053110
	Fagard M, Boutet S, Morel JB, Bellini C, Vaucheret H. AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals. Proc. Natl. Acad. Sci. U.S.A. 97 2000 11650-4 [PubMed: 11016954] http://dx.doi.org/10.1073/pnas.200217597
	Jacobsen SE, Running MP, Meyerowitz EM. Disruption of an RNA helicase/RNAse III gene in Arabidopsis causes unregulated cell division in floral meristems. Development 126 1999 5231-43 [PubMed: 10556049] http://dev.biologists.org/cgi/content/abstract/126/23/5231

InterPro 23.1