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InterPro: IPR002687 Pre-mRNA processing ribonucleoprotein, snoRNA-binding domain

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626 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR002687 SnoRNA-bd_dom

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01798	Nop	626
Signatures in BioMart

InterPro annotation

Entry Details in BioMart

Abstract

This domain is present in various pre-mRNA processing ribonucleoproteins. The function of the domain is unknown however it may be a common RNA or snoRNA or Nop1p binding domain.

Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functional spliceosome formation have also been described. Finally, growing evidence suggests that proteins may contribute directly to the spliceosome's active sites [1].

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SCOP: a.183.1.1

Database links Help

PANDIT: PF01798

Blocks: IPB002687

Taxonomic coverage Help

Example proteins Help

A6ZPE5 Nucleolar protein 58

O04656 Putative nucleolar protein 5-3

Q21276 Uncharacterized NOP5 family protein K07C5.4

Q6DFW4 Nucleolar protein 58

Q8WWY3 U4/U6 small nuclear ribonucleoprotein Prp31

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002687	Pre-mRNA processing ribonucleoprotein, snoRNA-binding domain
IPR019175	Prp31 C-terminal
IPR012976	NOSIC
IPR012974	NOP5, N-terminal
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Open in usermanual
1.	Will CL, Luhrmann R. Protein functions in pre-mRNA splicing. Curr. Opin. Cell Biol. 9 320-8 1997 [PubMed: 9159080] http://dx.doi.org/10.1016/S0955-0674(97)80003-8

Additional Reading Open in usermanual
	Wu P, Brockenbrough JS, Metcalfe AC, Chen S, Aris JP. Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast. J. Biol. Chem. 273 1998 16453-63 [PubMed: 9632712] http://dx.doi.org/10.1074/jbc.273.26.16453
	Gautier T, Berges T, Tollervey D, Hurt E. Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. Mol. Cell. Biol. 17 1997 7088-98 [PubMed: 9372940] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=9372940
	Aittaleb M, Rashid R, Chen Q, Palmer JR, Daniels CJ, Li H. Structure and function of archaeal box C/D sRNP core proteins. Nat. Struct. Biol. 10 2003 256-63 [PubMed: 12598892] http://dx.doi.org/10.1038/nsb905
	Weidenhammer EM, Singh M, Ruiz-Noriega M, Woolford JL Jr. The PRP31 gene encodes a novel protein required for pre-mRNA splicing in Saccharomyces cerevisiae. Nucleic Acids Res. 24 1996 1164-70 [PubMed: 8604353] http://dx.doi.org/10.1093/nar/24.6.1164

InterPro 23.1