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InterPro: IPR002646 Poly A polymerase, head domain

Protein matches Help

UniProtKB

Matches:

2592 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002646 PolA_pol_head_dom

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01743	PolyA_pol	2592
Signatures in BioMart

InterPro Relationships Help

Found in

IPR012006 tRNA nucleotidyltransferase, proteobacteria
IPR014065 tRNA adenylyltransferase

GO Term annotation Help

Process

GO:0006396 RNA processing

Function

GO:0003723 RNA binding
GO:0016779 nucleotidyltransferase activity

InterPro annotation

Entry Details in BioMart

Abstract

This group includes nucleic acid independent RNA polymerases, such as polynucleotide adenylyltransferase (EC:2.7.7.19), which adds the poly (A) tail to mRNA. This group also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25.

Structural links Help

PDB - click here

SCOP: d.218.1.4

CATH: 3.30.460.10

Database links Help

Enzyme: EC:2.7.7.21 , EC:2.7.7.25

PANDIT: PF01743

Blocks: IPB002646

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002646

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P21269 tRNA nucleotidyltransferase, mitochondrial

Q7SIB1 CCA-adding enzyme

Q8K1J6 tRNA-nucleotidyltransferase 1, mitochondrial

Q96Q11 tRNA-nucleotidyltransferase 1, mitochondrial

Q9P4S5 tRNA nucleotidyltransferase, mitochondrial

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002646	Poly A polymerase, head domain
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Cao GJ, Sarkar N. Identification of the gene for an Escherichia coli poly(A) polymerase. Proc. Natl. Acad. Sci. U.S.A. 89 1992 10380-4 [PubMed: 1438224] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=1438224&action=stream&blobtype=pdf
	Augustin MA, Reichert AS, Betat H, Huber R, Morl M, Steegborn C. Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization. J. Mol. Biol. 328 2003 985-94 [PubMed: 12729736] http://dx.doi.org/10.1016/S0022-2836(03)00381-4
	Li F, Xiong Y, Wang J, Cho HD, Tomita K, Weiner AM, Steitz TA. Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP. Cell 111 2002 815-24 [PubMed: 12526808] http://dx.doi.org/10.1016/S0092-8674(02)01115-7
	Tomita K, Fukai S, Ishitani R, Ueda T, Takeuchi N, Vassylyev DG, Nureki O. Structural basis for template-independent RNA polymerization. Nature 430 2004 700-4 [PubMed: 15295603] http://dx.doi.org/10.1038/nature02712

InterPro 23.1