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InterPro: IPR002627 tRNA isopentenyltransferase

Protein matches Help

UniProtKB

Matches:

2022 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002627 IPPT

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01715	IPPT	2003
PANTHER	PTHR11088	IPPT	1997
Signatures in BioMart

InterPro Relationships Help

Parent

IPR018022 tRNA delta(2)-isopentenylpyrophosphate transferase

GO Term annotation Help

Process

GO:0008033 tRNA processing

Function

GO:0004811 tRNA isopentenyltransferase activity
GO:0005524 ATP binding

InterPro annotation

Entry Details in BioMart

Abstract

tRNA isopentenyltransferases EC:2.5.1.8 also known as tRNA delta(2)-isopentenylpyrophosphate transferases or IPP transferases. These enzymes modify both cytoplasmic and mitochondrial tRNAs at A(37) to give isopentenyl A(37) [1].

Structural links Help

PDB - click here

CATH: 3.40.50.300

Database links Help

Enzyme: EC:2.5.1.8

PANDIT: PF01715

Blocks: IPB002627

Pfam Clan: CL0023.30

AC	CL0023.30
ID	AAA
DE	P-loop containing nucleoside triphosphate hydrolase superfamily
PF00004	IPR003959	ATPase, AAA-type, core
PF00005	IPR003439	ABC transporter-like
PF00158	IPR002078	RNA polymerase sigma factor 54, interaction
PF00265	IPR001267	Thymidine kinase
PF00308	IPR013317	Chromosomal replication control, initiator (DnaA)/regulator (Hda)
PF00406	IPR000850	Adenylate kinase
PF00437	IPR001482	Type II secretion system protein E
PF00485	IPR006083	Phosphoribulokinase/uridine kinase
PF00488	IPR000432	DNA mismatch repair protein MutS, C-terminal
PF00493	IPR001208	DNA-dependent ATPase MCM
PF00625	IPR008144	Guanylate kinase
PF00685	IPR000863	Sulfotransferase
PF00931	IPR002182	NB-ARC
PF01078	IPR000523	Magnesium chelatase, ChlI subunit
PF01202	IPR000623	Shikimate kinase
PF01580	IPR002543	Cell divisionFtsK/SpoIIIE
PF01583	IPR002891	Adenylylsulphate kinase, C-terminal
PF01637	IPR011579	ATPase domain, prokaryote
PF01656	IPR002586	Cobyrinic acid a,c-diamide synthase
PF01695	IPR002611	IstB-like ATP-binding protein
PF01712	IPR002624	Deoxynucleoside kinase
PF01715	IPR002627	tRNA isopentenyltransferase
PF01745	IPR002648	Isopentenyl transferase
PF01935	IPR002789	Protein of unknown function DUF87
PF02223	IPR000062	Thymidylate kinase-like
PF02224	IPR011994	Cytidylate kinase domain
PF02367	IPR003442	Uncharacterised protein family UPF0079, ATPase bacteria
PF02374	IPR003348	ATPase, anion-transporting
PF02463	IPR003395	RecF/RecN/SMC protein, N-terminal
PF02492	IPR003495	Cobalamin (vitamin B12) biosynthesis CobW-like
PF02534	IPR003688	TRAG protein
PF03205	IPR004435	Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB), conserved region
PF03215	IPR004582	Checkpoint protein Rad24
PF03308	IPR005129	ArgK protein
PF03668	IPR005337	ATPase, P-loop-containing
PF03969	IPR005654	ATPase, AFG1-like
PF05621	IPR008868	Bacterial TniB
PF05707	IPR008900	Zonular occludens toxin
PF05729	IPR007111	NACHT nucleoside triphosphatase
PF05872	IPR008571	Protein of unknown function DUF853, nucleotide triphosphate hydrolase, putative
PF06068	IPR010339	TIP49, C-terminal
PF06144	IPR010372	DNA polymerase III, delta
PF06309	IPR010448	Torsin
PF06431	IPR010932	Large T antigen, polyomavirus, C-terminal
PF07693	IPR011646	KAP P-loop
PF07724	IPR013093	ATPase associated with various cellular activities, AAA-2
PF07726	IPR011703	ATPase associated with various cellular activities, AAA-3
PF07728	IPR011704	ATPase associated with various cellular activities, AAA-5
PF07931	IPR012853	Chloramphenicol phosphotransferase-like
PF08298	IPR013153	PrkA AAA
PF08433	IPR013641	Chromatin associated protein KTI12
PF08542	IPR013748	Replication factor C
PF10443	IPR018850	Mitochondrial escape protein 2, putative NTP-binding domain
PF10609	IPR019591	ATPase-like, ParA/MinD

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002627

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P07884 tRNA isopentenyltransferase

P16384 tRNA Delta(2)-isopentenylpyrophosphate transferase

P74040 tRNA Delta(2)-isopentenylpyrophosphate transferase

Q80UN9 tRNA isopentenyltransferase, mitochondrial

Q9H3H1 tRNA isopentenyltransferase, mitochondrial

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR018022	tRNA delta(2)-isopentenylpyrophosphate transferase
IPR002627	tRNA isopentenyltransferase
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Boguta M, Hunter LA, Shen WC, Gillman EC, Martin NC, Hopper AK. Subcellular locations of MOD5 proteins: mapping of sequences sufficient for targeting to mitochondria and demonstration that mitochondrial and nuclear isoforms commingle in the cytosol. Mol. Cell. Biol. 14 2298-306 1994 [PubMed: 8139535] http://mcb.asm.org/cgi/content/abstract/14/4/2298

Additional Reading Open in usermanual
	Durand JM, Bjork GR, Kuwae A, Yoshikawa M, Sasakawa C. The modified nucleoside 2-methylthio-N6-isopentenyladenosine in tRNA of Shigella flexneri is required for expression of virulence genes. J. Bacteriol. 179 1997 5777-82 [PubMed: 9294434] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=9294434
	Gillman EC, Slusher LB, Martin NC, Hopper AK. MOD5 translation initiation sites determine N6-isopentenyladenosine modification of mitochondrial and cytoplasmic tRNA. Mol. Cell. Biol. 11 1991 2382-90 [PubMed: 1850093] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=1850093
	Xie W, Zhou C, Huang RH. Structure of tRNA dimethylallyltransferase: RNA modification through a channel. J. Mol. Biol. 367 2007 872-81 [PubMed: 17292915] http://dx.doi.org/10.1016/j.jmb.2007.01.048

InterPro 23.1