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InterPro: IPR002478 Pseudouridine synthase/archaeosine transglycosylase
Protein matches
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UniProtKB Matches: 3012 proteins |
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Accession
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IPR002478 PUA |
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Type
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Domain |
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Signatures
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InterPro Relationships
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Parent
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IPR015947 Pseudouridine synthase/archaeosine transglycosylase-like
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Children
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IPR004521 Uncharacterised domain 2
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Found in
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IPR004802 Pseudouridine synthase, putative
IPR004804 Archaeosine tRNA-ribosyltransferase
IPR005155 Ribosome biogenesis factor NIP7-like
IPR005715 Glutamate 5-kinase, ProB-related
IPR011529 Glutamate 5-kinase, pro-B
IPR016686 Ribosome biogenesis factor, NIP7
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GO Term annotation
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Function
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GO:0003723 RNA binding
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InterPro annotation
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 Entry Details in BioMart
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Abstract
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The PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was named after the proteins in which it was first found [1]. PUA is a highly conserved RNA-binding motif found in a wide range of archaeal, bacterial and eukaryotic proteins, including enzymes that catalyse tRNA and rRNA post-transcriptional modifications, proteins involved in ribosome biogenesis and translation, as well as in enzymes involved in proline biosynthesis [2, 3]. The structures of several PUA-RNA complexes reveal a common RNA recognition surface, but also some versatility in the way in which the motif binds to RNA [4]. PUA motifs are involved in dyskeratosis congenita and cancer, pointing to links between RNA metabolism and human diseases [5].
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Structural links
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Database links
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Pfam Clan: CL0178.12
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Publications
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1.
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Aravind L, Koonin EV.
Novel predicted RNA-binding domains associated with the translation machinery.
J. Mol. Evol. 48 291-302 1999
[PubMed: 10093218]
http://dx.doi.org/10.1007/PL00006472
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2.
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Hallberg BM, Ericsson UB, Johnson KA, Andersen NM, Douthwaite S, Nordlund P, Beuscher AE 4th, Erlandsen H.
The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain.
J. Mol. Biol. 360 774-87 2006
[PubMed: 16793063]
http://dx.doi.org/10.1016/j.jmb.2006.05.047
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3.
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Sabina J, Soll D.
The RNA-binding PUA domain of archaeal tRNA-guanine transglycosylase is not required for archaeosine formation.
J. Biol. Chem. 281 6993-7001 2006
[PubMed: 16407303]
http://dx.doi.org/10.1074/jbc.M512841200
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4.
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Perez-Arellano I, Gallego J, Cervera J.
The PUA domain - a structural and functional overview.
FEBS J. 274 4972-84 2007
[PubMed: 17803682]
http://dx.doi.org/10.1111/j.1742-4658.2007.06031.x
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5.
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Li L, Ye K.
Crystal structure of an H/ACA box ribonucleoprotein particle.
Nature 443 302-7 2006
[PubMed: 16943774]
http://dx.doi.org/10.1038/nature05151
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Additional Reading
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Rashid R, Liang B, Baker DL, Youssef OA, He Y, Phipps K, Terns RM, Terns MP, Li H.
Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita.
Mol. Cell 21 2006 249-60
[PubMed: 16427014]
http://dx.doi.org/10.1016/j.molcel.2005.11.017
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Liang B, Xue S, Terns RM, Terns MP, Li H.
Substrate RNA positioning in the archaeal H/ACA ribonucleoprotein complex.
Nat. Struct. Mol. Biol. 2007
[PubMed: 18059286]
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Phannachet K, Elias Y, Huang RH.
Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase.
Biochemistry 44 2005 15488-94
[PubMed: 16300397]
http://dx.doi.org/10.1021/bi050961w
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Hamma T, Reichow SL, Varani G, Ferre-D'Amare AR.
The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs.
Nat. Struct. Mol. Biol. 12 2005 1101-7
[PubMed: 16286935]
http://dx.doi.org/10.1038/nsmb1036
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Ishitani R, Nureki O, Fukai S, Kijimoto T, Nameki N, Watanabe M, Kondo H, Sekine M, Okada N, Nishimura S, Yokoyama S.
Crystal structure of archaeosine tRNA-guanine transglycosylase.
J. Mol. Biol. 318 2002 665-77
[PubMed: 12054814]
http://dx.doi.org/10.1016/S0022-2836(02)00090-6
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InterPro 23.1
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