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InterPro: IPR002343 Paraneoplastic encephalomyelitis antigen

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UniProtKB

Matches:

421 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002343 Hud_Sxl_RNA

Type

Family

Signatures Help

Database	ID	Name	Proteins
PRINTS	PR00961	HUDSXLRNA	421
Signatures in BioMart

InterPro Relationships Help

Children

IPR006546 Sex-lethal splicing factor
IPR006548 Splicing factor ELAV/HuD

Contains

IPR000504 RNA recognition motif, RNP-1

GO Term annotation Help

Function

GO:0003723 RNA binding

InterPro annotation

Entry Details in BioMart

Abstract

Many eukaryotic proteins that are either known or thought to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids [1, 2]. This region has been found in, for example, heterogeneous nuclear ribonucleoproteins, small nuclear ribonucleoproteins, pre-RNA and mRNA associated proteins, Drosophila sex determination and elav proteins, human paraneoplastic encephalomyelitis antigen HuD, and many others. The structure of an RNA-binding domain of Drosophila Sex-lethal (Sxl) protein has been determined using multi-dimensional hetero-nuclear NMR [3]. Sxl contains two RNP consensus-type RNA-binding domains (RBDs) - the determined structure represents the second of these (RBD-2) [3]. The calculated intermediate-resolution family of structures exhibits the beta-alpha-beta/beta-alpha-beta tertiary fold found in other RBD-containing proteins [3].

Structural links Help

PDB - click here

SCOP: d.58.7.1

CATH: 3.30.70.330

Database links Help

Blocks: IPB002343

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002343

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A4IIM2 CUG-BP- and ETR-3-like factor 2

P19339 Protein sex-lethal

P26378 ELAV-like protein 4

P42731 Polyadenylate-binding protein 2

Q60900 ELAV-like protein 3

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR012677	Nucleotide-binding, alpha-beta plait
IPR006546	Sex-lethal splicing factor
IPR006548	Splicing factor ELAV/HuD
IPR000504	RNA recognition motif, RNP-1
IPR002343	Paraneoplastic encephalomyelitis antigen
IPR006515	Polyadenylate binding protein, human types 1, 2, 3, 4
IPR015903	Ribonucleoprotein, BRUNO-like
IPR002004	Polyadenylate-binding protein/Hyperplastic disc protein
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Bandziulis RJ, Swanson MS, Dreyfuss G. RNA-binding proteins as developmental regulators. Genes Dev. 3 431-7 1989 [PubMed: 2470643] http://www.genesdev.org/cgi/content/abstract/3/4/431
2.	Dreyfuss G, Swanson MS, Pinol-Roma S. Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation. Trends Biochem. Sci. 13 86-91 1988 [PubMed: 3072706] http://dx.doi.org/10.1016/0968-0004(88)90046-1
3.	Lee AL, Kanaar R, Rio DC, Wemmer DE. Resonance assignments and solution structure of the second RNA-binding domain of sex-lethal determined by multidimensional heteronuclear magnetic resonance. Biochemistry 33 13775-86 1994 [PubMed: 7524663] http://dx.doi.org/10.1021/bi00250a031

Additional Reading Open in usermanual
	Handa N, Nureki O, Kurimoto K, Kim I, Sakamoto H, Shimura Y, Muto Y, Yokoyama S. Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein. Nature 398 1999 579-85 [PubMed: 10217141] http://dx.doi.org/10.1038/19242
	Crowder SM, Kanaar R, Rio DC, Alber T. Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal. Proc. Natl. Acad. Sci. U.S.A. 96 1999 4892-7 [PubMed: 10220389] http://dx.doi.org/10.1073/pnas.96.9.4892
	Inoue M, Muto Y, Sakamoto H, Yokoyama S. NMR studies on functional structures of the AU-rich element-binding domains of Hu antigen C. Nucleic Acids Res. 28 2000 1743-50 [PubMed: 10734193] http://dx.doi.org/10.1093/nar/28.8.1743
	Inoue M, Muto Y, Sakamoto H, Kigawa T, Takio K, Shimura Y, Yokoyama S. A characteristic arrangement of aromatic amino acid residues in the solution structure of the amino-terminal RNA-binding domain of Drosophila sex-lethal. J. Mol. Biol. 272 1997 82-94 [PubMed: 9299339] http://dx.doi.org/10.1006/jmbi.1997.1213
	Wang X, Tanaka Hall TM. Structural basis for recognition of AU-rich element RNA by the HuD protein. Nat. Struct. Biol. 8 2001 141-5 [PubMed: 11175903] http://dx.doi.org/10.1038/84131

InterPro 23.1