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InterPro: IPR001566 23S rRNA methyltransferase/RumA

Protein matches Help

UniProtKB

Matches:

1588 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR001566 RumA_MeTrfase

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR00479	rumA	1588
Signatures in BioMart

InterPro Relationships Help

Parent

IPR010280 (Uracil-5)-methyltransferase

Contains

IPR002792 Deoxyribonuclease/rho motif-related TRAM
IPR016027 Nucleic acid-binding, OB-fold-like

GO Term annotation Help

Process

GO:0006396 RNA processing

Function

GO:0003723 RNA binding
GO:0008173 RNA methyltransferase activity

InterPro annotation

Entry Details in BioMart

Abstract

This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from Escherichia coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA [1].

Structural links Help

PDB - click here

SCOP: b.40.4.12 , c.66.1.40

Database links Help

Enzyme: EC:2.1.1

Blocks: IPB001566

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001566

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P55135 23S rRNA (uracil-5-)-methyltransferase rumA

P73374 Uncharacterized RNA methyltransferase sll1967

Q7NGN4 Uncharacterized RNA methyltransferase gll3134

Q9UZR7 Uncharacterized RNA methyltransferase PYRAB10780

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002792	Deoxyribonuclease/rho motif-related TRAM
IPR010280	(Uracil-5)-methyltransferase
IPR001566	23S rRNA methyltransferase/RumA
IPR016027	Nucleic acid-binding, OB-fold-like
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Open in usermanual
1.	Agarwalla S, Kealey JT, Santi DV, Stroud RM. Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. J. Biol. Chem. 277 8835-40 2002 [PubMed: 11779873] http://dx.doi.org/10.1074/jbc.M111825200

Additional Reading Open in usermanual
	Lee TT, Agarwalla S, Stroud RM. A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function. Cell 120 2005 599-611 [PubMed: 15766524] http://dx.doi.org/10.1016/j.cell.2004.12.037
	Lee TT, Agarwalla S, Stroud RM. Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase. Structure 12 2004 397-407 [PubMed: 15016356] http://dx.doi.org/10.1016/j.str.2004.02.009

InterPro 23.1