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InterPro: IPR001040 Eukaryotic translation initiation factor 4E (eIF-4E)

Protein matches Help

UniProtKB

Matches:

806 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR001040 TIF_eIF_4E

Type

Family

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:3.30.760.10	TIF_eIF_4E	772
Pfam	PF01652	IF4E	741
PANTHER	PTHR11960	TIF_eIF_4E	766
SuperFamily	SSF55418	TIF_eIF_4E	802
Signatures in BioMart

InterPro Relationships Help

Contains

IPR019770 Eukaryotic translation initiation factor 4E (eIF-4E), conserved site

GO Term annotation Help

Process

GO:0006413 translational initiation

Function

GO:0003723 RNA binding
GO:0003743 translation initiation factor activity

Component

GO:0005737 cytoplasm

InterPro annotation

Entry Details in BioMart

Abstract

Eukaryotic translation initiation factor 4E (eIF-4E) [1] is a protein that binds to the cap structure of eukaryotic cellular mRNAs. eIF-4E recognises and binds the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiation of protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding of its secondary structures. A tryptophan in the central part of the sequence of human eIF-4E seems to be implicated in cap-binding [2].

Structural links Help

PDB - click here

SCOP: d.86.1.1

CATH: 3.30.760.10

Database links Help

PDBe-motif: PS00813

PROSITE doc: PDOC00641

PANDIT: PF01652

Blocks: IPB001040

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001040

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O45551 Eukaryotic translation initiation factor 4E-1

O60573 Eukaryotic translation initiation factor 4E type 2

P07260 Eukaryotic translation initiation factor 4E

P48598 Eukaryotic translation initiation factor 4E

P63073 Eukaryotic translation initiation factor 4E

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR001040	Eukaryotic translation initiation factor 4E (eIF-4E)
IPR019770	Eukaryotic translation initiation factor 4E (eIF-4E), conserved site
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Thach RE. Cap recap: the involvement of eIF-4F in regulating gene expression. Cell 68 177-180 1992 [PubMed: 1733496] http://dx.doi.org/10.1016/0092-8674(92)90461-K
2.	Ueda H, Iyo H, Doi M, Inoue M, Ishida T, Morioka H, Tanaka T, Nishikawa S, Uesugi S. Combination of Trp and Glu residues for recognition of mRNA cap structure. Analysis of m7G base recognition site of human cap binding protein (IF-4E) by site-directed mutagenesis. FEBS Lett. 280 207-10 1991 [PubMed: 1672854] http://dx.doi.org/10.1016/0014-5793(91)80294-D

Additional Reading Open in usermanual
	Brown CJ, McNae I, Fischer PM, Walkinshaw MD. Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives. J. Mol. Biol. 372 2007 7-15 [PubMed: 17631896] http://dx.doi.org/10.1016/j.jmb.2007.06.033
	Gross JD, Moerke NJ, von der Haar T, Lugovskoy AA, Sachs AB, McCarthy JE, Wagner G. Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell 115 2003 739-50 [PubMed: 14675538] http://dx.doi.org/10.1016/S0092-8674(03)00975-9
	Tomoo K, Matsushita Y, Fujisaki H, Abiko F, Shen X, Taniguchi T, Miyagawa H, Kitamura K, Miura K, Ishida T. Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. Biochim. Biophys. Acta 1753 2005 191-208 [PubMed: 16271312] http://dx.doi.org/10.1016/j.bbapap.2005.07.023
	Tomoo K, Shen X, Okabe K, Nozoe Y, Fukuhara S, Morino S, Ishida T, Taniguchi T, Hasegawa H, Terashima A, Sasaki M, Katsuya Y, Kitamura K, Miyoshi H, Ishikawa M, Miura K. Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region. Biochem. J. 362 2002 539-44 [PubMed: 11879179] http://dx.doi.org/10.1042/0264-6021:3620539
	Niedzwiecka A, Marcotrigiano J, Stepinski J, Jankowska-Anyszka M, Wyslouch-Cieszynska A, Dadlez M, Gingras AC, Mak P, Darzynkiewicz E, Sonenberg N, Burley SK, Stolarski R. Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J. Mol. Biol. 319 2002 615-35 [PubMed: 12054859] http://dx.doi.org/10.1016/S0022-2836(02)00328-5

InterPro 23.1