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InterPro: IPR000442 Intron maturase, type II

Protein matches Help

UniProtKB

Matches:

19349 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR000442 Intron_maturse2

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01348	Intron_maturas2	19349
Signatures in BioMart

GO Term annotation Help

Process

GO:0008380 RNA splicing

InterPro annotation

Entry Details in BioMart

Abstract

Group II introns use intron-encoded reverse transcriptase, maturase and DNA endonuclease activities for site-specific insertion into DNA [1]. Although this type of intron is self splicing in vitro they require a maturase protein for splicing in vivo. It has been shown that a specific region of the aI2 intron is needed for the maturase function [2]. This region was found to be conserved in group II introns and called domain X [3].

Database links Help

PANDIT: PF01348

Blocks: IPB000442

Taxonomic coverage Help

Example proteins Help

P03875 Putative COX1/OXI3 intron 1 protein

P05511 Uncharacterized 91 kDa protein in cob intron

P0A3U0 Group II intron-encoded protein ltrA

P0C381 Maturase K

P56784 Maturase K

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000442	Intron maturase, type II
IPR015706	RNA-directed DNA polymerase (reverse transcriptase), related
IPR003615	HNH nuclease
IPR000883	Cytochrome c oxidase, subunit I
IPR000477	RNA-directed DNA polymerase (reverse transcriptase)
IPR002866	Maturase, MatK, N-terminal
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Guo H, Zimmerly S, Perlman PS, Lambowitz AM. Group II intron endonucleases use both RNA and protein subunits for recognition of specific sequences in double-stranded DNA. EMBO J. 16 6835-48 1997 [PubMed: 9362497] http://dx.doi.org/10.1093/emboj/16.22.6835
2.	Moran JV, Mecklenburg KL, Sass P, Belcher SM, Mahnke D, Lewin A, Perlman P. Splicing defective mutants of the COXI gene of yeast mitochondrial DNA: initial definition of the maturase domain of the group II intron aI2. Nucleic Acids Res. 22 2057-64 1994 [PubMed: 8029012] http://dx.doi.org/10.1093/nar/22.11.2057
3.	Mohr G, Perlman PS, Lambowitz AM. Evolutionary relationships among group II intron-encoded proteins and identification of a conserved domain that may be related to maturase function. Nucleic Acids Res. 21 4991-7 1993 [PubMed: 8255751] http://dx.doi.org/10.1093/nar/21.22.4991

InterPro 23.1