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InterPro: IPR000330 SNF2-related

Protein matches Help

UniProtKB

Matches:

5692 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR000330 SNF2_N

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF00176	SNF2_N	5692
Signatures in BioMart

InterPro Relationships Help

Contains

IPR014001 DEAD-like helicase, N-terminal

GO Term annotation Help

Function

GO:0003677 DNA binding
GO:0005524 ATP binding

InterPro annotation

Entry Details in BioMart

Abstract

This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1) [1, 2]. SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilises energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.

Proteins that contain this domain appear to be distantly related to the DEAX box helicases IPR001410, however no helicase activity has ever been demonstrated for these proteins.

Structural links Help

PDB - click here

SCOP: c.37.1.19

Database links Help

Enzyme: EC:3.6.1

PANDIT: PF00176

Blocks: IPB000330

Pfam Clan: CL0008.22

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR000330

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A2AJK6 Chromodomain-helicase-DNA-binding protein 7

O14646 Chromodomain-helicase-DNA-binding protein 1

P32657 Chromo domain-containing protein 1

P41877 Chromatin-remodeling complex ATPase chain isw-1

Q24368 Chromatin-remodeling complex ATPase chain Iswi

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000953	Chromo domain
IPR006576	BRK domain
IPR015195	SLIDE
IPR012287	Homeodomain-related
IPR017956	AT hook, DNA-binding motif
IPR016197	Chromo domain-like
IPR014021	Helicase, superfamily 1/2, ATP-binding domain
IPR015194	ATPase, nucleosome remodelling ISWI, HAND domain
IPR001650	DNA/RNA helicase, C-terminal
IPR001005	SANT, DNA-binding
IPR017884	SANT, eukarya
IPR014001	DEAD-like helicase, N-terminal
IPR000330	SNF2-related
IPR009057	Homeodomain-like
	PDB Chain
	ModBase
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Eisen JA, Sweder KS, Hanawalt PC. Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions. Nucleic Acids Res. 23 2715-23 1995 [PubMed: 7651832] http://dx.doi.org/10.1093/nar/23.14.2715
2.	Linder B, Cabot RA, Schwickert T, Rupp RA. The SNF2 domain protein family in higher vertebrates displays dynamic expression patterns in Xenopus laevis embryos. Gene 326 59-66 2004 [PubMed: 14729263] http://dx.doi.org/10.1016/j.gene.2003.09.053

Additional Reading Open in usermanual
	Durr H, Korner C, Muller M, Hickmann V, Hopfner KP. X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA. Cell 121 2005 363-73 [PubMed: 15882619] http://dx.doi.org/10.1016/j.cell.2005.03.026
	Thoma NH, Czyzewski BK, Alexeev AA, Mazin AV, Kowalczykowski SC, Pavletich NP. Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54. Nat. Struct. Mol. Biol. 12 2005 350-6 [PubMed: 15806108] http://dx.doi.org/10.1038/nsmb919

InterPro 23.1