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InterPro: IPR000061 SWAP/Surp

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481 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR000061 Surp

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01805	Surp	450
PROSITE profile	PS50128	SURP	456
SMART	SM00648	SWAP	463
Signatures in BioMart

GO Term annotation Help

Process

GO:0006396 RNA processing

Function

GO:0003723 RNA binding

InterPro annotation

Entry Details in BioMart

Abstract

SWAP is derived from the Suppressor-of-White-APricot splicing regulator from Drosophila melanogaster. The domain is found in regulators responsible for pervasive, nonsex-specific alternative pre-mRNA splicing characteristics and has been found in splicing regulatory proteins [1]. These ancient, conserved SWAP proteins share a colinearly arrayed series of novel sequence motifs [2].

Structural links Help

PDB - click here

SCOP: a.217.1.1

Database links Help

PROSITE doc: PDOC50128

PANDIT: PF01805

Blocks: IPB000061

Taxonomic coverage Help

Example proteins Help

P12297 Protein suppressor of white apricot

P32524 Pre-mRNA-splicing factor PRP21

Q10580 Protein SWAP

Q15459 Splicing factor 3 subunit 1

Q8CH02 Splicing factor 4

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000467	D111/G-patch
IPR000626	Ubiquitin
IPR000061	SWAP/Surp
IPR019147	Splicing factor, suppressor of white apricot
IPR019955	Ubiquitin supergroup
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Open in usermanual
1.	Denhez F, Lafyatis R. Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot. J. Biol. Chem. 269 16170-9 1994 [PubMed: 8206918] http://intl.jbc.org/cgi/content/abstract/269/23/16170
2.	Spikes DA, Kramer J, Bingham PM, Van Doren K. SWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins. Nucleic Acids Res. 22 4510-9 1994 [PubMed: 7971282] http://dx.doi.org/10.1093/nar/22.21.4510

Additional Reading Open in usermanual
	Kuwasako K, He F, Inoue M, Tanaka A, Sugano S, Guntert P, Muto Y, Yokoyama S. Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP. Structure 14 2006 1677-89 [PubMed: 17098193] http://dx.doi.org/10.1016/j.str.2006.09.009
	Rain JC, Tartakoff AM, Kramer A, Legrain P. Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution. RNA 2 1996 535-50 [PubMed: 8718683] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=8718683

InterPro 23.1