EC 6.5.1.2 - DNA ligase (NAD+)

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IntEnz Enzyme Nomenclature
EC 6.5.1.2

Names

Accepted name:
DNA ligase (NAD+)
Other names:
DNA joinase [ambiguous]
DNA ligase [ambiguous]
DNA ligase (NAD)
DNA repair enzyme [ambiguous]
DNA-joining enzyme [ambiguous]
deoxyribonucleate ligase [ambiguous]
deoxyribonucleic acid joinase [ambiguous]
deoxyribonucleic acid ligase [ambiguous]
deoxyribonucleic joinase [ambiguous]
deoxyribonucleic ligase [ambiguous]
deoxyribonucleic repair enzyme [ambiguous]
deoxyribonucleic-joining enzyme [ambiguous]
polydeoxyribonucleotide synthase (NAD)
polydeoxyribonucleotide synthase (NAD+)
polynucleotide ligase [ambiguous]
polynucleotide ligase (NAD)
polynucleotide ligase (nicotinamide adenine dinucleotide)
polynucleotide synthetase [ambiguous]
polynucleotide synthetase (nicotinamide adenine dinucleotide)
Systematic name:
poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)

Reaction

Comments:

Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA. RNA can also act as substrate, to some extent. cf. EC 6.5.1.1, DNA ligase (ATP), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00809
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003911
CAS Registry Number: 37259-52-2
UniProtKB/Swiss-Prot: (876) [show] [UniProt]

References

  1. Zimmerman, S.B., Little, J.W., Oshinsky, C.K. and Gellert, M.
    Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide.
    Proc. Natl. Acad. Sci. USA 57: 1841-1848 (1967). [PMID: 4291949]

[EC 6.5.1.2 created 1972, modified 1976]