EC 6.5.1.1 - DNA ligase (ATP)

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IntEnz Enzyme Nomenclature
EC 6.5.1.1

Names

Accepted name:
DNA ligase (ATP)
Other names:
DNA joinase [ambiguous]
DNA ligase [ambiguous]
DNA repair enzyme [ambiguous]
DNA-joining enzyme [ambiguous]
deoxyribonucleate ligase [ambiguous]
deoxyribonucleic acid joinase [ambiguous]
deoxyribonucleic acid ligase [ambiguous]
deoxyribonucleic acid repair enzyme [ambiguous]
deoxyribonucleic acid-joining enzyme [ambiguous]
deoxyribonucleic joinase [ambiguous]
deoxyribonucleic ligase [ambiguous]
deoxyribonucleic repair enzyme [ambiguous]
deoxyribonucleic-joining enzyme [ambiguous]
polydeoxyribonucleotide synthase (ATP)
polynucleotide ligase [ambiguous]
sealase
polynucleotide ligase (ATP)
Systematic name:
poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)

Reaction

Comments:

Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA. RNA can also act as substrate, to some extent. cf. EC 6.5.1.2, DNA ligase (NAD+), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00295
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003910
CAS Registry Number: 9015-85-4
UniProtKB/Swiss-Prot: (182) [show] [UniProt]

References

  1. Becker, A., Lyn, G., Gefter, M. and Hurwitz, J.
    The enzymatic repair of DNA. II. Characterization of phage-induced sealase.
    Proc. Natl. Acad. Sci. USA 58: 1996-2003 (1967). [PMID: 4295584]
  2. Bertazzoni, U., Mathelet, M. and Campagnari, F.
    Purification and properties of a polynucleotide ligase from calf thymus glands.
    Biochim. Biophys. Acta 287: 404-414 (1972). [PMID: 4641251]
  3. Weiss, B. and Richardson, C.C.
    Enzymatic breakage and joining of deoxyribonucleic acid. I. Repair of single-strand breaks in DNA by an enzyme system from Escherichia coli infected with T4 bacteriophage.
    Proc. Natl. Acad. Sci. USA 57: 1021-1028 (1967). [PMID: 5340583]

[EC 6.5.1.1 created 1972, modified 1976]