EC - Acetyl-CoA carboxylase

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IntEnz Enzyme Nomenclature


Accepted name:
acetyl-CoA carboxylase
Other name:
acetyl coenzyme A carboxylase
Systematic name:
acetyl-CoA:carbon-dioxide ligase (ADP-forming)




A biotinyl-protein. Also catalyses transcarboxylation; the plant enzyme also carboxylates propanonyl-CoA and butanoyl-CoA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00167 , PROSITE:PDOC00676 , PROSITE:PDOC50979 , PROSITE:PDOC50980
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003989
CAS Registry Number: 9023-93-2
UniProtKB/Swiss-Prot: (1009) [show] [UniProt]


  1. Hatch, M.D. and Stumpf, P.K.
    Fat metabolism in higher plants. XVI. Acetyl coenzyme A carboxylase and acyl coenzyme A-malonyl coenzyme A transcarboxylase from wheat germ.
    J. Biol. Chem. 236: 2879-2885 (1961). [PMID: 13905314]
  2. Matsuhashi, M., Matsuhashi, S. and Lynen, F.
    Zur Biosynthese der Fettsäuren. V. Die Acetyl-CoA Carboxylase aus Rattenleber und ihre Aktivierung durch Citronsäure.
    Biochem. Z. 340: 263-289 (1964). [PMID: 14317958]
  3. Matsuhashi, M., Matsuhashi, S., Numa, S. and Lynen, F.
    [On the biosynthesis of fatty acids. IV. Acetyl-CoA carboxylase from yeast.](in German)
    Biochem. Z. 340: 243-262 (1964). [PMID: 14317957]
  4. Vagelos, P.
    Regulation of fatty acid biosynthesis.
    Curr. Top. Cell. Regul. 4: 119-166 (1971).
  5. Wakil, S.J.
    A malonic acid derivative as an intermediate in fatty acid synthesis.
    J. Am. Chem. Soc. 80: 6465 (1958).

[EC created 1961]