EC 6.3.3.4 - (carboxyethyl)arginine β-lactam-synthase

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IntEnz Enzyme Nomenclature
EC 6.3.3.4

Names

Accepted name:
(carboxyethyl)arginine β-lactam-synthase
Other names:
β-lactam synthetase
L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming)
Systematic name:
L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming)

Reaction

Comments:

Forms part of the pathway for the biosythesis of the β-lactamase inhibitor clavulanate in Streptomyces clavuligerus. It has been proposed [3] that L-N2-(2-carboxyethyl)arginine is first converted into an acyl-AMP by reaction with ATP and loss of diphosphate, and that the β-lactam ring is then formed by the intramolecular attack of the β-nitrogen on the activated carboxy group.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0034027
UniProtKB/Swiss-Prot:

References

  1. Zhou, J., Kelly, W.L., Bachmann, B.O., Gunsior, M., Townsend, C.A. and Solomon, E.I.
    Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional α-KG-dependent non-heme iron enzyme: Correlation with mechanisms and reactivities.
    J. Am. Chem. Soc. 123: 7388-7398 (2001).
  2. Townsend, C.A.
    New reactions in clavulanic acid biosynthesis.
    Curr. Opin. Chem. Biol. 6: 583-589 (2002). [PMID: 12413541]
  3. Bachmann, B.O., Li, R. and Townsend, C.A.
    β-Lactam synthetase: a new biosynthetic enzyme.
    Proc. Natl. Acad. Sci. USA 95: 9082-9086 (1998). [PMID: 9689037]

[EC 6.3.3.4 created 2003]