EC 6.3.2.2
- Glutamate—cysteine ligase
IntEnz Enzyme Nomenclature
EC 6.3.2.2
Names
Accepted name:
glutamate—cysteine ligase
Other
names:
γ-glutamyl-L-cysteine synthetase
γ-glutamylcysteine synthetase
γ-glutamylcysteinyl synthetase
Systematic name:
L-glutamate:L-cysteine γ-ligase (ADP-forming)
Reaction
-
L-cysteine
L-cysteine
Name origin:
UniProt - CHECKED (C)
Formula:
C3H7NO2S
Charge: 0
ChEBI compound status: CHECKED (C)
+
L-glutamate
L-glutamate
Name origin:
UniProt - CHECKED (C)
Formula:
C5H8NO4
Charge: -1
ChEBI compound status: CHECKED (C)
+
ATP
ATP
Name origin:
UniProt - CHECKED (C)
Formula:
C10H12N5O13P3
Charge: -4
ChEBI compound status: CHECKED (C)
<?>
L-γ-glutamyl-L-cysteine
L-gamma-glutamyl-L-cysteine
Name origin:
UniProt - CHECKED (C)
Formula:
C8H13N2O5S
Charge: -1
ChEBI compound status: CHECKED (C)
+
ADP
ADP
Name origin:
UniProt - CHECKED (C)
Formula:
C10H12N5O10P2
Charge: -3
ChEBI compound status: CHECKED (C)
+
H+
H(+)
Name origin:
UniProt - CHECKED (C)
Formula:
H
Charge: 1
ChEBI compound status: CHECKED (C)
+
phosphate
phosphate
Name origin:
UniProt - CHECKED (C)
Formula:
HO4P
Charge: -2
ChEBI compound status: CHECKED (C)
Comments:
Can use L-aminohexanoate in place of glutamate.
Links to other databases
CAS Registry Number:
9023-64-7
EGTA_MYCS2
EGTA_MYCTO
EGTA_MYCTU
GCS21_ARTS2
GCS21_COREF
GCS21_FRAAA
GCS21_FRACC
GCS21_LEGPA
GCS21_LEGPC
GCS21_LEGPL
GCS21_MYCS2
GCS21_MYCSJ
GCS21_MYCSK
GCS21_MYCVP
GCS21_NOCFA
GCS21_NOCSJ
GCS21_PAEAT
GCS21_RHOJR
GCS21_RUBXD
GCS21_SACEN
GCS21_STRAW
GCS22_ARTS2
GCS22_COREF
GCS22_FRAAA
GCS22_FRACC
GCS22_LEGPA
GCS22_LEGPC
GCS22_LEGPL
GCS22_MYCS2
GCS22_MYCSJ
GCS22_MYCSK
GCS22_MYCVP
GCS22_NOCFA
GCS22_NOCSJ
GCS22_PAEAT
GCS22_RHOJR
GCS22_RUBXD
GCS22_SACEN
GCS22_STRAW
GCS23_FRAAA
GCS23_MYCS2
GCS23_NOCSJ
GCS23_PAEAT
GCS23_RHOJR
GCS23_RUBXD
GCS24_RHOJR
GCS2_ACIAC
GCS2_ACIET
GCS2_ACISJ
GCS2_ANAVT
GCS2_AZOC5
GCS2_AZOSB
GCS2_BDEBA
GCS2_BORA1
GCS2_BORBR
GCS2_BORPA
GCS2_BORPD
GCS2_BORPE
GCS2_BRADU
GCS2_BRASB
GCS2_BRASO
GCS2_BURA4
GCS2_BURCA
GCS2_BURCC
GCS2_BURCH
GCS2_BURCJ
GCS2_BURCM
GCS2_BURL3
GCS2_BURM1
GCS2_BURM7
GCS2_BURM9
GCS2_BURMA
GCS2_BURMS
GCS2_BURP0
GCS2_BURP1
GCS2_BURP6
GCS2_BURPS
GCS2_BURTA
GCS2_BURVG
GCS2_CHLAA
GCS2_CHLAD
GCS2_CHLSY
GCS2_CHRVO
GCS2_CITK8
GCS2_CLAM3
GCS2_CLAMS
GCS2_CORDI
GCS2_CORGB
GCS2_CORGL
GCS2_CORJK
GCS2_CORU7
GCS2_CROS8
GCS2_CUPMC
GCS2_CUPNH
GCS2_CUPNJ
GCS2_CUPTR
GCS2_DECAR
GCS2_DINSH
GCS2_ECO24
GCS2_ECO27
GCS2_ECO45
GCS2_ECO55
GCS2_ECO57
GCS2_ECO5E
GCS2_ECO7I
GCS2_ECO81
GCS2_ECO8A
GCS2_ECOBW
GCS2_ECOHS
GCS2_ECOK1
GCS2_ECOL5
GCS2_ECOL6
GCS2_ECOLC
GCS2_ECOLI
GCS2_ECOLU
GCS2_ECOSE
GCS2_ECOSM
GCS2_ECOUT
GCS2_ENT38
GCS2_ESCF3
GCS2_GLOVI
GCS2_HALLT
GCS2_HALMA
GCS2_HALS3
GCS2_HALSA
GCS2_HALVD
GCS2_HALWD
GCS2_HERA2
GCS2_HERAR
GCS2_JANMA
GCS2_JANSC
GCS2_KLEP3
GCS2_KLEP7
GCS2_LARHH
GCS2_LEGPH
GCS2_LEIXX
GCS2_LEPCP
GCS2_METPP
GCS2_MICLC
GCS2_MYCA1
GCS2_MYCBO
GCS2_MYCBP
GCS2_MYCBT
GCS2_MYCPA
GCS2_MYCSS
GCS2_MYCTA
GCS2_MYCTO
GCS2_MYCTU
GCS2_MYCUA
GCS2_NATPD
GCS2_NITMU
GCS2_PARDP
GCS2_PARPJ
GCS2_PARXL
GCS2_POLNA
GCS2_POLSJ
GCS2_PSEA7
GCS2_PSEA8
GCS2_PSEAB
GCS2_PSEAE
GCS2_PSEE4
GCS2_PSEF5
GCS2_PSEMY
GCS2_PSEPK
GCS2_RALPJ
GCS2_RALSO
GCS2_RHOBA
GCS2_RHORT
GCS2_ROSCS
GCS2_ROSS1
GCS2_RUEPO
GCS2_SALA4
GCS2_SALAI
GCS2_SALAR
GCS2_SALCH
GCS2_SALDC
GCS2_SALEP
GCS2_SALG2
GCS2_SALHS
GCS2_SALNS
GCS2_SALPA
GCS2_SALPB
GCS2_SALPC
GCS2_SALPK
GCS2_SALSV
GCS2_SALTI
GCS2_SALTO
GCS2_SALTY
GCS2_SHIBS
GCS2_SHIDS
GCS2_SHIF8
GCS2_SHIFL
GCS2_SHISS
GCS2_SOLUE
GCS2_SORC5
GCS2_STRCO
GCS2_THEFY
GCS2_VEREI
GSH1A_ORYSI
GSH1A_ORYSJ
GSH1B_ORYSI
GSH1B_ORYSJ
GSH1_ALCBS
GSH1_ALISL
GSH1_ARATH
GSH1_AZOVD
GSH1_BAUCH
GSH1_BORBR
GSH1_BORPA
GSH1_BORPD
GSH1_BRAJU
GSH1_BUCA5
GSH1_BUCAI
GSH1_BUCAP
GSH1_BUCAT
GSH1_BUCBP
GSH1_CAEEL
GSH1_CANAX
GSH1_CITK8
GSH1_CLOAB
GSH1_CROS8
GSH1_DICDI
GSH1_DROME
GSH1_ECO24
GSH1_ECO27
GSH1_ECO45
GSH1_ECO55
GSH1_ECO57
GSH1_ECO5E
GSH1_ECO7I
GSH1_ECO81
GSH1_ECO8A
GSH1_ECOBW
GSH1_ECODH
GSH1_ECOHS
GSH1_ECOL5
GSH1_ECOL6
GSH1_ECOLC
GSH1_ECOLI
GSH1_ECOLU
GSH1_ECOSE
GSH1_ECOSM
GSH1_ECOUT
GSH1_EDWI9
GSH1_ENT38
GSH1_ERWT9
GSH1_ESCF3
GSH1_HAHCH
GSH1_HUMAN
GSH1_JANMA
GSH1_KLEP3
GSH1_KLEP7
GSH1_LEPIC
GSH1_LEPIN
GSH1_MEDTR
GSH1_MOUSE
GSH1_NEUCR
GSH1_ONCVO
GSH1_PECAS
GSH1_PECCP
GSH1_PHOLL
GSH1_PHOPR
GSH1_PROMH
GSH1_PSE14
GSH1_PSEA7
GSH1_PSEA8
GSH1_PSEAB
GSH1_PSEAE
GSH1_PSEE4
GSH1_PSEF5
GSH1_PSEHT
GSH1_PSEMY
GSH1_PSEPF
GSH1_PSEPK
GSH1_PSEPW
GSH1_PSESM
GSH1_PSESY
GSH1_PSEU2
GSH1_PSEU5
GSH1_RAT
GSH1_SACD2
GSH1_SALA4
GSH1_SALAR
GSH1_SALCH
GSH1_SALDC
GSH1_SALEP
GSH1_SALG2
GSH1_SALHS
GSH1_SALNS
GSH1_SALPA
GSH1_SALPB
GSH1_SALPC
GSH1_SALPK
GSH1_SALSV
GSH1_SALTI
GSH1_SALTY
GSH1_SCHPO
GSH1_SERP5
GSH1_SHEAM
GSH1_SHEHH
GSH1_SHEON
GSH1_SHEPA
GSH1_SHIB3
GSH1_SHIBS
GSH1_SHIDS
GSH1_SHIF8
GSH1_SHISS
GSH1_SODGM
GSH1_SOLLC
GSH1_TOBAC
GSH1_VIBCB
GSH1_VIBCH
GSH1_VIBF1
GSH1_VIBFM
GSH1_VIBPA
GSH1_VIBVU
GSH1_VIBVY
GSH1_WIGBR
GSH1_YEAST
GSH1_YERE8
GSH1_YERPE
GSH1_YERPS
GSHAB_CLOPE
GSHAB_DESPS
GSHAB_ENTFA
GSHAB_LACPL
GSHAB_LISIN
GSHAB_LISMF
GSHAB_LISMO
GSHAB_LISW6
GSHAB_MANSM
GSHAB_PASMU
GSHAB_STRA3
GSHAB_STRA5
GSHAB_STRMU
GSHAB_STRT1
GSHAB_STRT2
References
-
Mackinnon, C.M., Carter, P.E., Smyth, S.J., Dunbar, B. and Fothergill, J.E.
Molecular-cloning of cDNA for human-complement component C1s - the complete amino-acid sequence.
Eur. J. Biochem.
169:
547-553
(1987).
[PMID:
3500856]
-
Snoke, J.E., Yanari, S. and Bloch, K.
Synthesis of glutathione from γ-glutamylcysteine.
J. Biol. Chem.
201:
573-586
(1953).
[PMID:
13061393]
-
Mandeles, S. and Bloch, K.
Enzymatic synthesis of γ-glutamylcysteine.
J. Biol. Chem.
214:
639-646
(1955).
[EC 6.3.2.2 created 1961]