EC 6.3.2.13 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase

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IntEnz Enzyme Nomenclature
EC 6.3.2.13

Names

Accepted name:
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase
Other names:
MurE synthetase [ambiguous]
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming)
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase
UDP-N-acetylmuramyl-tripeptide synthetase
UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diaminopimelate ligase
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate γ-ligase (ADP-forming)
Systematic name:
UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate γ-ligase (ADP-forming)

Reaction

Comments:

Involved in the synthesis of a cell-wall peptide. This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase) adds lysine instead. It is the amino group of the L-centre of the diaminopimelate that is acylated.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008765
CAS Registry Number: 9075-09-6
UniProtKB/Swiss-Prot: (147) [show] [UniProt]

References

  1. Mizuno, Y. and Ito, E.
    Purification and properties of uridine diphosphate N-acetylmuramyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase.
    J. Biol. Chem. 243: 2665-2672 (1968). [PMID: 4967958]
  2. van Heijenoort, J.
    Recent advances in the formation of the bacterial peptidoglycan monomer unit.
    Nat. Prod. Rep. 18: 503-519 (2001). [PMID: 11699883]

[EC 6.3.2.13 created 1972, modified 2002, modified 2010]