EC - Succinate—CoA ligase (GDP-forming)

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IntEnz Enzyme Nomenclature


Accepted name:
succinate—CoA ligase (GDP-forming)
Other names:
succinate thiokinase
succinate-phosphorylating enzyme
succinic thiokinase
succinyl CoA synthetase
succinyl coenzyme A synthetase
succinyl coenzyme A synthetase (GDP-forming)
succinyl coenzyme A synthetase (guanosine diphosphate-forming)
succinyl-CoA synthetase (GDP-forming)
Systematic name:
succinate:CoA ligase (GDP-forming)



Itaconate can act instead of succinate, and ITP instead of GTP.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00335
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004776
CAS Registry Number: 9014-36-2
UniProtKB/Swiss-Prot: (18) [show] [UniProt]


  1. Hager, L.P
    Succinyl CoA synthetase
    In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes,, 2nd ed. vol. 6, Academic Press, New York, 1962, 387-399
  2. Kaufman, S., Gilvarg, C., Cori, O. and Ochoa, S.
    Enzymatic oxidation of α-ketoglutarate and coupled phosphorylation.
    J. Biol. Chem. 203: 869-888 (1953).
  3. Mazumder, R., Sanadi, D.R. and Rodwell, W.V.
    Purification and properties of hog kidney succinic thiokinase.
    J. Biol. Chem. 235: 2546-2550 (1960).
  4. Sanadi, D.R., Gibson, D.M. and Ayengar, P.
    Guanosine triphosphate, the primary product of phosphorylation coupled to the breakdown of succinyl coenzyme A.
    Biochim. Biophys. Acta 14: 434-436 (1954).

[EC created 1961]