EC 5.99.1.2 - DNA topoisomerase

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IntEnz Enzyme Nomenclature
EC 5.99.1.2

Names

Accepted name:
DNA topoisomerase
Other names:
ω-protein
deoxyribonucleate topoisomerase
nicking-closing enzyme
relaxing enzyme
swivelase
topoisomerase
type I DNA topoisomerase
untwisting enzyme
Systematic name:
DNA topoisomerase

Reaction

Comments:

These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.99.1.3 DNA topoisomerase (ATP-hydrolysing).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00159 , PROSITE:PDOC00333
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003917
CAS Registry Number: 80449-01-0
UniProtKB/Swiss-Prot: (138) [show] [UniProt]

References

  1. Gellert, M.
    DNA topoisomerases.
    Annu. Rev. Biochem. 50: 879-910 (1981). [PMID: 6267993]

[EC 5.99.1.2 created 1984]