EC 22.214.171.124 - β-phosphoglucomutase
IntEnz Enzyme Nomenclature
20116 [IUBMB]β-D-glucose 1-phosphatebeta-D-glucose 1-phosphateName origin: UniProt - CHECKED (C)Formula: C6H11O9P
Charge: -2ChEBI compound status: CHECKED (C)<=>
The enzyme requires Mg2+ and phosphorylation of an aspartate residue at the active site. The enzyme is able to autophosphorylate itself with its substrate β-D-glucose 1-phosphate. Although this is a slow reaction, only a single turnover is required for activation. Once the phosphorylated enzyme is formed, it generates the reaction intermediate β-D-glucose 1,6-bisphosphate, which can be used to phosphorylate the enzyme in subsequent cycles . cf. EC 126.96.36.199, phosphoglucomutase (β-D-glucose-1,6-bisphosphate-dependent).
Links to other databases
A phosphoglucomutase specific for β-glucose 1-phosphate.J. Biol. Chem. 236: 2186-2189 (1961).
Phosphomutases,In: Boyer, P.D. (Ed.) The Enzymes, 3rd ed. vol. 6, Academic Press, New York, 1972, 407-477
The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction.Science 299: 2067-2071 (2003). [PMID: 12637673]
Conformational cycling in beta-phosphoglucomutase catalysis: reorientation of the beta-D-glucose 1,6-(Bis)phosphate intermediate.Biochemistry 45: 7818-7824 (2006). [PMID: 16784233]
[EC 188.8.131.52 created 1984]