EC 5.4.2.6 - β-phosphoglucomutase

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IntEnz Enzyme Nomenclature
EC 5.4.2.6

Names

Accepted name:
β-phosphoglucomutase
Other name:
β-pgm (gene name)
Systematic name:
β-D-glucose 1,6-phosphomutase

Reaction

Comments:

The enzyme requires Mg2+ and phosphorylation of an aspartate residue at the active site. The enzyme is able to autophosphorylate itself with its substrate β-D-glucose 1-phosphate. Although this is a slow reaction, only a single turnover is required for activation. Once the phosphorylated enzyme is formed, it generates the reaction intermediate β-D-glucose 1,6-bisphosphate, which can be used to phosphorylate the enzyme in subsequent cycles [4]. cf. EC 5.4.2.2, phosphoglucomutase (β-D-glucose-1,6-bisphosphate-dependent).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008801
UniProtKB/Swiss-Prot:

References

  1. Ben-Zvi, R. and Schramm, M.
    A phosphoglucomutase specific for β-glucose 1-phosphate.
    J. Biol. Chem. 236: 2186-2189 (1961).
  2. Ray, W.J., Jr. and Peck, E.J., Jr.
    Phosphomutases,
    In: Boyer, P.D. (Ed.) The Enzymes, 3rd ed. vol. 6, Academic Press, New York, 1972, 407-477
  3. Lahiri, S. D., Zhang, G., Dunaway-Mariano, D., Allen, K. N.
    The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction.
    Science 299: 2067-2071 (2003). [PMID: 12637673]
  4. Dai, J., Wang, L., Allen, K. N., Radstrom, P., Dunaway-Mariano, D.
    Conformational cycling in beta-phosphoglucomutase catalysis: reorientation of the beta-D-glucose 1,6-(Bis)phosphate intermediate.
    Biochemistry 45: 7818-7824 (2006). [PMID: 16784233]

[EC 5.4.2.6 created 1984]