EC 5.4.2.10 - Phosphoglucosamine mutase

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IntEnz Enzyme Nomenclature
EC 5.4.2.10

Names

Accepted name:
phosphoglucosamine mutase
Other name:
D-glucosamine 1,6-phosphomutase
Systematic name:
α-D-glucosamine 1,6-phosphomutase

Reaction

Comments:

The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis. The enzyme from Escherichia coli is activated by phosphorylation and can be autophosphorylated in vitro by α-D-glucosamine 1,6-bisphosphate, which is an intermediate in the reaction, α-D-glucose 1,6-bisphosphate or ATP. It can also catalyse the interconversion of α-D-glucose 1-phosphate and glucose 6-phosphate, although at a much lower rate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008966
UniProtKB/Swiss-Prot: (686) [show] [UniProt]

References

  1. Mengin-Lecreulx, D. and van Heijenoort, J.
    Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli.
    J. Biol. Chem. 271: 32-39 (1996). [PMID: 8550580]
  2. de Reuse, H., Labigne, A. and Mengin-Lecreulx, D.
    The Helicobacter pylori ureC gene codes for a phosphoglucosamine mutase.
    J. Bacteriol. 179: 3488-3493 (1997). [PMID: 9171391]
  3. Jolly, L., Wu, S., van Heijenoort, J., de Lencastre, H., Mengin-Lecreulx, D. and Tomas, A.
    The femR315 gene from Staphylococcus aureus, the interruption of which results in reduced methicillin resistance, encodes a phosphoglucosamine mutase.
    J. Bacteriol. 179: 5321-5325 (1997). [PMID: 9286983]
  4. Jolly, L., Ferrari, P., Blanot, D., van Heijenoort, J., Fassy, F. and Mengin-Lecreulx, D.
    Reaction mechanism of phosphoglucosamine mutase from Escherichia coli.
    Eur. J. Biochem. 262: 202-210 (1999). [PMID: 10231382]
  5. Jolly, L., Pompeo, F., van Heijenoort, J., Fassy, F. and Mengin-Lecreulx, D.
    Autophosphorylation of phosphoglucosamine mutase from Escherichia coli.
    J. Bacteriol. 182: 1280-1285 (2000). [PMID: 10671448]

[EC 5.4.2.10 created 2001]