EC 5.3.99.5 - Thromboxane-A synthase

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IntEnz Enzyme Nomenclature
EC 5.3.99.5

Names

Accepted name:
thromboxane-A synthase
Other names:
(5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase
thromboxane synthase
thromboxane synthetase
Systematic name:
(5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase

Reaction

Cofactor

Comments:

A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004796
UniProtKB/Swiss-Prot:

References

  1. Shen, R.-F. and Tai, H.-H.
    Immunoaffinity purification and characterization of thromboxane synthase from porcine lung.
    J. Biol. Chem. 261: 11592-11599 (1986). [PMID: 3745158]
  2. Ullrich, V. and Haurand, M.
    Thromboxane synthase as a cytochrome P450 enzyme.
    Adv. Prostaglandin Thromboxane Leukot. Res. 11: 105-110 (1983).

[EC 5.3.99.5 created 1984, modified 1990]