EC 5.3.99.4 - Prostaglandin-I synthase

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IntEnz Enzyme Nomenclature
EC 5.3.99.4

Names

Accepted name:
prostaglandin-I synthase
Other names:
PGI2 synthase
PGI2 synthetase
prostacyclin synthase
prostacycline synthetase
prostagladin I2 synthetase
Systematic name:
(5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase

Reaction

Cofactor

Comments:

A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into prostaglandin I2 (prostacyclin).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008116
UniProtKB/Swiss-Prot:

References

  1. DeWitt, D.L. and Smith, W.L.
    Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein.
    J. Biol. Chem. 258: 3285-3293 (1983). [PMID: 6338016]
  2. Ullrich, V., Castle, L. and Weber, P.
    Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase.
    Biochem. Pharmacol. 30: 2033-2036 (1981). [PMID: 7023490]

[EC 5.3.99.4 created 1984, modified 1990]