EC - Dodecenoyl-CoA isomerase

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IntEnz Enzyme Nomenclature


Accepted name:
dodecenoyl-CoA isomerase
Other names:
Δ3-cis2-trans-enoyl-CoA isomerase
acetylene-allene isomerase
dodecenoyl-CoA Δ-isomerase
dodecenoyl-CoA Δ3-cis2-trans-isomerase
Δ32-enoyl-CoA isomerase
3,2-trans-enoyl-CoA isomerase
Systematic name:
dodecenoyl-CoA (3Z)-(2E)-isomerase



Also catalyses the interconversion of 3-acetylenic fatty acyl thioesters and (+)-2,3-dienoyl fatty acyl thioesters, with fatty acid chain lengths C6 to C12.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004165
CAS Registry Number: 62213-29-0
UniProtKB/Swiss-Prot: (144) [show] [UniProt]


  1. Miesowicz, F.M. and Bloch, K.
    Purification of hog liver isomerase. Mechanism of isomerization of 3-alkenyl and 3-alkynyl thioesters.
    J. Biol. Chem. 254: 5868-5877 (1979). [PMID: 376522]
  2. Stoffel, W., Ditzer, R. and Caesar, H.
    Der Stoffwechsel der ungesättigten Fettsäuren. III. Zur β-Oxydation der Mono- und Polyenfettsäuren. Der Mechanismus der enzymatischen Reaktionen an Δ3cis-Enoyl-CoA-Verbindungen.
    Hoppe-Seyler's Z. Physiol. Chem. 339: 167-181 (1964). [PMID: 5830064]
  3. Stoffel, W. and Ecker, W.
    Δ3-cis,-Δ2-trans-Enoyl-CoA isomerase from rat liver mitochondria.
    Methods Enzymol. 14: 99-105 (1979).
  4. Stoffel, W. and Grol, M.
    Purification and properties of 3-cis-2-trans-enoyl-CoA isomerase (dodecenoyl-CoA Δ-isomerase) from rat liver mitochondria.
    Hoppe-Seyler's Z. Physiol. Chem. 359: 1777-1782 (1978). [PMID: 738702]

[EC created 1978, modified 1980]